Chronic Disease Management for Older Adults

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Chronic Care".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 616

Special Issue Editor


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Guest Editor
School of Science, Department of Physical Education, Universidade Estadual Paulista "Júlio de Mesquita Filho", Bauru 17033360, SP, Brazil
Interests: aging; physical exercise; chronic disease; hypertension; blood pressure regulation

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a manuscript to Healthcare in the Special Issue entitled “Chronic Disease Management for Older Adults”. It is already scientifically known that there is an increase in the incidence of chronic diseases with advancing age, especially hypertension and diabetes. Conversely, lifestyle changes have been considered the main non-pharmacological approach to prevent or assist the treatment of these diseases. However, the effectiveness of strategies is linked to a complete understanding of the factors leading to the onset of chronic diseases and, mainly, the effect of the interventions on the control of hypertension, for example. A better understanding of these relationships could significantly contribute to a more effective prevention and treatment action and, consequently, provide a better quality of life for older adults.

This Special Issue aims to discuss the management of chronic disease in older adults and how the changes in lifestyle contribute to counteracting these unwanted effects of aging.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Management of chronic disease in older adults, especially hypertension and diabetes;
  • Change in lifestyle (healthy diet, physical activity, tobacco consumption, harmful use of alcohol, and excess weight).

I look forward to receiving your contributions.

Dr. Anderson Saranz Zago
Guest Editor

Manuscript Submission Information

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Keywords

  • chronic disease
  • hypertension
  • diabetes
  • quality of life
  • aging
  • physical exercise
  • healthy diet

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Published Papers (1 paper)

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Research

13 pages, 501 KiB  
Article
Comparative Analyses Between Vulnerability Biomarkers of Aging and Health Biomarkers in Middle-Aged and Older Female Adults
by Klara Karin Brigitte Knoblauch, Luana Froes Losnack, Gustavo Castillo Zacarias, Gabriel Gasparini Satyro, Rodrigo Villar and Anderson Saranz Zago
Healthcare 2025, 13(6), 667; https://doi.org/10.3390/healthcare13060667 - 18 Mar 2025
Viewed by 413
Abstract
Biological aging is normally associated with greater physiological changes which predispose individuals to adverse outcomes. In this way, the evaluation of vulnerability biomarkers and their relationships with other health biomarkers could contribute to the promotion of interventions and the improvement of older adults’ [...] Read more.
Biological aging is normally associated with greater physiological changes which predispose individuals to adverse outcomes. In this way, the evaluation of vulnerability biomarkers and their relationships with other health biomarkers could contribute to the promotion of interventions and the improvement of older adults’ quality of life. Thereby, this study aimed to compare vulnerability biomarkers (Growth Differentiation Factor 15 (GDF-15), General Functional Fitness Index (GFFI), and frailty phenotype) and their influence on health markers (blood biochemistry, body composition, and hemodynamic variables) in middle-aged and older female adults. Methods: A cross-sectional observational study was conducted with community-dwelling females aged 54–84 with at least 6 months of experience with physical training. The participants were categorized based on functional fitness, frailty phenotype, and GDF-15 quartiles. The General Functional Fitness Index (GFFI) was assessed using the AAHPERD test battery, while frailty phenotype was determined using Fried’s criteria. GDF-15 levels were measured through ELISA. Results: A higher training status (TS) showed better functional fitness and favorable biochemical profiles, including lower total cholesterol (p = 0.006, η2p = 0.253), LDL cholesterol (p = 0.001, η2p = 0.346), triglycerides (p = 0.048, η2p = 0.195), and systolic blood pressure (p = 0.001, η2p = 0.333). Individuals classified as robust (non-frail) had better physical performance and lower total cholesterol (p = 0.002, η2p = 0.306) and LDL cholesterol (p = 0.014, η2p = 0.216) compared to those classified as frail and pre-frail. The GDF-15 quartile did not present differences in health markers between groups. Conclusions: These findings suggest that GFFI may be considered a health biomarker for middle-aged and female older adults while highlighting the need for further research on the role of biomarkers of vulnerability and healthy aging. Full article
(This article belongs to the Special Issue Chronic Disease Management for Older Adults)
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