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Healthcare
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Medication Therapy Management in Healthcare
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Medication Therapy Management in Healthcare

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Medication Management".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1837

Special Issue Editors

Dr. Wubshet Tesfaye

E-Mail Website
Guest Editor
School of Pharmacy, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane 4072, Australia
Interests: chronic kidney disease; medication appropriateness index; medication regimen complexity index; the elderly
Special Issues, Collections and Topics in MDPI journals
Dr. Akshaya Srikanth Bhagavathula

E-Mail Website
Guest Editor
Department of Public Health, North Dakota State University, Fargo, ND, USA
Interests: public health; technology; health promotion; disease prevention; adherence; reproductive health; chronic diseases; epidemiology; biostatistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medications are crucial interventions not only for treating various disease conditions but also for preventing disease progression, morbidity and mortality. Medication therapy management or medication review is a strategy widely employed by pharmacists and other health workers to optimize drug therapy with the goal of improving therapeutic outcomes for patients. It comprises different components, such as comprehensive medication review, identifying and addressing potentially inappropriate medications and medication-related needs, developing a pharmaceutical care plan, and identifying and addressing patient monitoring, referral and education requirements.

This Special Issue aims to produce a robust and unique set of evidence on medication therapy management or medication review models in different settings and across the healthcare continuum, innovative approaches used to implement those models, and understanding the effectiveness of such models in improving health, patient-reported, and economic outcomes.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  • Medication therapy management approaches in chronic conditions, such as diabetes, hypertension, cardiovascular conditions, and chronic kidney disease.
  • Effectiveness of medication therapy management or medication review models.
  • Cost-effectiveness of medication therapy management or medication review models.
  • Innovative solutions to improve the effectiveness of medication therapy management.
  • Multidisciplinary medication review models (mainly focusing on those containing pharmacists) to improve therapeutic drug outcomes.

I look forward to receiving your contributions.

Dr. Wubshet Tesfaye
Dr. Akshaya Srikanth Bhagavathula
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • medication appropriateness index
  • medication regimen complexity index
  • the elderly

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

13 pages, 1730 KiB  
Article
Self-Study-Based Informed Decision-Making Tool for Empowerment of Treatment Adherence Among Chronic Heart Failure Patients—A Pilot Study
by Lea Iten, Kevin Selby, Celine Glauser, Sara Schukraft and Roger Hullin
Healthcare 2025, 13(6), 685; https://doi.org/10.3390/healthcare13060685 - 20 Mar 2025
Viewed by 234
Abstract
Background: Adherence to drug prescriptions is often suboptimal among heart failure (HF) patients. Informed decision-making may improve patients’ adherence to HF drug prescriptions. Aims of the study: We aimed to test whether a self-study-based informed decision-making tool could improve adherence to drug prescriptions [...] Read more.
Background: Adherence to drug prescriptions is often suboptimal among heart failure (HF) patients. Informed decision-making may improve patients’ adherence to HF drug prescriptions. Aims of the study: We aimed to test whether a self-study-based informed decision-making tool could improve adherence to drug prescriptions among ambulatory HF patients. Methods: A tool and a statement-based questionnaire were developed to evaluate drug adherence willingness based on COMPAR-EU recommendations. The test group (n = 40) was exposed to the tool + questionnaire; controls (n = 40) answered the questionnaire only. Agreement with statements of the questionnaire was graded on a scale of 0 to 4 points, reflecting no to full agreement. Results: The median age of controls was younger (56 vs. 61 years; p = 0.04); test and control group patients did not differ across other parameters (always p > 0.05). Patients in both groups agreed that “HF is a life-long disease” (3.5 vs. 4; p = 0.19) and that “only life-long drug treatment provides benefit” (4 vs. 4; p = 0.22). More test group patients confirmed improved comprehension of HF disease (3 vs. 2; p = 0.03) and greater acceptance that “achievement of benefit asks for a combination of HF drugs” (4 vs. 3; p = 0.009) and “daily intake” (4 vs. 3; p = 0.004). In test group patients, questions remained, resulting in less agreement that “all aspects of my heart disease” are understood (1 vs. 3; p < 0.001). Willingness to adhere to HF-drug treatment was not different between the groups (3 vs. 3.5; p = 0.28). Conclusions: The self-study-based informed decision-making tool improved the comprehension of HF and the need for HF treatment, but did not improve willingness to adhere since questions remained unanswered. Full article
(This article belongs to the Special Issue Medication Therapy Management in Healthcare)
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9 pages, 243 KiB  
Article
Medication Regimen Complexity and Patient-Centred Outcomes in Patients Undergoing Peritoneal Dialysis
by Jing Xin Goh, Kamal Sud, Wubshet Tesfaye, Connie Van, Shrey Seth, Surjit Tarafdar and Ronald L. Castelino
Healthcare 2024, 12(21), 2121; https://doi.org/10.3390/healthcare12212121 - 24 Oct 2024
Viewed by 1264
Abstract
Background: Although patients undergoing peritoneal dialysis (PD) typically have complex treatment needs, the effect of medication regimen complexity on patient outcomes has not been thoroughly evaluated. This study aims to quantify medication regimen complexity and evaluate patient-centred outcomes including medication adherence and its [...] Read more.
Background: Although patients undergoing peritoneal dialysis (PD) typically have complex treatment needs, the effect of medication regimen complexity on patient outcomes has not been thoroughly evaluated. This study aims to quantify medication regimen complexity and evaluate patient-centred outcomes including medication adherence and its determinants in patients undergoing PD. Methods: This study combined a retrospective audit of baseline data with a prospective evaluation of patient-related outcomes among patients undergoing PD at a large metropolitan dialysis centre in Australia. Medication regimen complexity was assessed using the 65-item Medication Regimen Complexity Index (MRCI), while patient outcomes were evaluated with validated self-reported questionnaires, including the 4-item Morisky–Green–Levine Scale (MGLS), EQ-5D-5L and EQ VAS. Results: A total of 131 patients participated [median age 67 (IQR 57–74) years]. Patients on PD were found to have complex medication regimens with an average MRCI score of 28.6 ± 11.4. Over half of the participants were deemed to be adherent to their prescribed medications as measured by the MGLS (n = 79; 60.3%). Male participants were more likely to be non-adherent to medications compared to female participants (OR 2.465; 95% CI 1.055–5.759). Participants with higher serum phosphate levels were 2.5 times more likely to report non-adherence to their medications (OR 2.523; 95% CI 1.247–5.104), while a higher health-related quality of life (HRQoL) was associated with medication adherence (OR 0.151, 95% CI 0.031–0.732). Conclusions: Patients on PD are prescribed complex medication regimens in addition to PD treatments that they perform at home. Patients on PD who were adherent to their medications had significantly better outcomes in terms of HRQoL and serum phosphate levels compared to non-adherent patients. Full article
(This article belongs to the Special Issue Medication Therapy Management in Healthcare)
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