Emerging Risk Factors and Prognosis of Stroke: Global Health Perspective

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Environmental Factors and Global Health".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 5426

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Institute of Applied Health Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK
Interests: health services research; dementia; cardiovascular diseases; healthy ageing
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Special Issue Information

Dear Colleagues,

Stroke is one of the leading causes of mortality and morbidity globally. Changing lifestyle and environments as well as emerging novel diseases may contribute to stroke risk in addition to well established risk factors. In addition, age is a risk factor for stroke and with the increasing ageing populations, the incidence and prevalence of stroke is likely to increase but rate of such an increase may vary depending on the world region. It is also increasingly acknowledged that there may be gender/sex differences in risk factors which may also have different impact depending on their age. Prognosis of acute and long term phase of stroke is an important issue in making clinical decisions. In this special issue, we are interested in broad range of topics related to healthcare of stroke with a focus on risk factors and prognosis from global perspective.

We look forward to receiving your contributions.

Prof. Dr. Phyo Kyaw Myint
Guest Editor

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Keywords

  • stroke
  • age and gender-specific prediction
  • care and prognosis
  • novel risk factors
  • global health
  • ethnicity

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Published Papers (2 papers)

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Review

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13 pages, 570 KiB  
Review
Recommendations for Upper Limb Motor Recovery: An Overview of the UK and European Rehabilitation after Stroke Guidelines (2023)
by Daniel O’Flaherty and Khalid Ali
Healthcare 2024, 12(14), 1433; https://doi.org/10.3390/healthcare12141433 - 18 Jul 2024
Viewed by 3587
Abstract
Upper limb impairment is common after stroke, with a significant impact on the stroke survivor’s function, social participation and quality of life. Clinical guidelines are needed to inform clinical practise, tailor interventions to improve outcomes and address unresolved research questions. This review contributes [...] Read more.
Upper limb impairment is common after stroke, with a significant impact on the stroke survivor’s function, social participation and quality of life. Clinical guidelines are needed to inform clinical practise, tailor interventions to improve outcomes and address unresolved research questions. This review contributes to the evidence guiding clinical practise for upper limb motor recovery after stroke by summarising the recommendations from the UK rehabilitation guidelines (National Institute for Health and Care Excellence (NICE) and the Intercollegiate Stroke Working Party (ISWP)) and the European Stroke Organisation (ESO) guidelines, all published in 2023. All three guidelines target researchers, clinical practitioners, stroke survivors and their social networks. An important feature in all three guidelines was therapeutic intensity, with all guidelines recommending increased therapeutic intensity. Unlike the ESO, the NICE and ISWP additionally include specific research recommendations. While the NICE guidelines seem more holistic and target a wider audience, the three guidelines are complimentary. We recommend that a future consensus statement should be developed in partnership between all three organisations, agreeing on scope and using the same terminology, on recommendations to improve stroke rehabilitation in the UK and Europe. Full article
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Other

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10 pages, 482 KiB  
Brief Report
Pre-Stroke Frailty and Outcomes following Percutaneous Endoscopic Gastrostomy Tube Insertion
by Karan Gupta, Eleanor Williams, Elizabeth A. Warburton and Nicholas Richard Evans
Healthcare 2024, 12(16), 1557; https://doi.org/10.3390/healthcare12161557 - 6 Aug 2024
Viewed by 1045
Abstract
Background: Frailty is common in stroke, where it exerts disease- and treatment-modifying effects. However, there has been little work evaluating how frailty influences outcomes after percutaneous endoscopic gastrostomy (PEG) tube insertion. This study investigates the relationship between pre-stroke frailty and one-year mortality following [...] Read more.
Background: Frailty is common in stroke, where it exerts disease- and treatment-modifying effects. However, there has been little work evaluating how frailty influences outcomes after percutaneous endoscopic gastrostomy (PEG) tube insertion. This study investigates the relationship between pre-stroke frailty and one-year mortality following PEG insertion. Methods: A pre-stroke frailty index (FI) was calculated for individuals with post-stroke dysphagia who underwent PEG insertion between March 2019 and February 2021. Mortality was recorded at one year, as well as instances of post-PEG pneumonia and discharge destination. Results: Twenty-nine individuals underwent PEG insertion, eleven (37.9%) of whom died in the subsequent year. The mean (SD) FI for those who survived was 0.10 (0.09), compared to 0.27 (0.19) for those who died (p = 0.02). This remained significant after adjustment for age and sex, with each 0.1 increase in the FI independently associated with an increased odds of one-year mortality (aOR 1.39, 95% CI 1.17–1.67). There was no association between frailty and post-PEG pneumonia (0.12 (0.21) in those who aspirated versus 0.11 (0.18) in those who did not, p = 0.75). Conclusions: Pre-stroke frailty is associated with increased one-year mortality after PEG, a finding that may help inform shared clinical decision-making in complex decisions regarding PEG feeding. Full article
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