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Healthcare
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Real-Life Advances in Chronic Kidney Disease
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Real-Life Advances in Chronic Kidney Disease

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Chronic Care".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 1454

Special Issue Editors

Dr. Guido Gembillo

E-Mail Website
Guest Editor
Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
Interests: clinical nephrology; chronic kidney disease; glomerulonephritis; diabetic kidney disease; hypertension; thrombotic microangiopathies; renal tubular acidosis; acute kidney injury; dialysis; vitamin D; vascular access
Special Issues, Collections and Topics in MDPI journals
Dr. Vincenzo Calabrese

E-Mail Website
Guest Editor Assistant
Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy
Interests: acid-bases disorders; chronic kidney diseases; electrolytes; epidemiology; hemodialysis; hypertension; nephrology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a paper based on real-life experiences with chronic kidney disease (CKD) to our Special Issue, entitled "Real-Life Advances in Chronic Kidney Disease".

This Special Issue aims to focus on real-life data, which should support the data retrieved from randomized clinical trials.

Real-life analysis allows us to generate hypotheses, highlight relevant clinical questions, suggest practice diagnostic or management advances, conduct surveys, and carry out drug surveillance.

In this Special Issue, original research articles and reviews are welcome to be submitted, as well as brief reports/surveys, commentary about the socioeconomic burden of chronic care, and systematic reviews of observational studies. Research areas may include, but are not limited to, the following: dialysis advances, domiciliary management, electrolyte disorders and complications related to them, management of CKD, quality of life, socioeconomic evaluation, and telemedicine in CKD.

Furthermore, papers about nursing topics will be well received, as they will fit within our scope of promoting nursing research, which we consider relevant in clinical practice.

We look forward to receiving your contributions.

Dr. Guido Gembillo
Guest Editor

Dr. Vincenzo Calabrese
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic diseases
  • dialysis
  • domiciliary management
  • electrolytes
  • nursing research
  • quality of life
  • socioeconomic evaluation
  • telemedicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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7 pages, 7911 KiB  
Case Report
Successful Management of Calciphylaxis with Sodium Thiosulfate in End-Stage Renal Disease: A Case Report
by Mohamed A. Albekery, Munirah K. Alkulaib, Ahmed A. Alanazi, Lulwah T. Alturki, Muthana A. Al Sahlawi, Ramy I. Abulikailik and Elbadri I. Abdelgadir
Healthcare 2025, 13(3), 282; https://doi.org/10.3390/healthcare13030282 - 31 Jan 2025
Viewed by 1238
Abstract
Introduction: Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare and potentially fatal condition primarily affecting patients with end-stage renal disease (ESRD) on hemodialysis (HD). It is characterized by calcification in small blood vessels, leading to painful skin ulcers and high [...] Read more.
Introduction: Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare and potentially fatal condition primarily affecting patients with end-stage renal disease (ESRD) on hemodialysis (HD). It is characterized by calcification in small blood vessels, leading to painful skin ulcers and high mortality rates. Case Description: This is a case of a 42-year-old female with ESRD on HD who developed calciphylaxis, presenting with non-healing ulcers on her thighs. Discussion: Despite initial treatments, including wound care and pain management, her condition did not improve. A skin biopsy was inconclusive, highlighting the diagnostic challenges associated with calciphylaxis. Based on clinical judgment, warfarin and calcium-based therapies were discontinued, and the patient’s HD regimen was adjusted. Due to the persistence of symptoms, sodium thiosulfate (STS) therapy was initiated, leading to significant improvement in her ulcers after six months of treatment. Conclusions: This case highlights the importance of clinical judgment in the diagnosis and management of calciphylaxis, particularly when histopathological diagnostic methods yield inconclusive results. Clinical criteria, alongside a thorough assessment of the patient’s history and presentation, are vital for achieving a timely diagnosis in such challenging cases. The successful use of sodium thiosulfate in this patient adds to the growing body of evidence supporting its use as a potential treatment for calciphylaxis, especially in cases that do not respond to conventional therapy. Full article
(This article belongs to the Special Issue Real-Life Advances in Chronic Kidney Disease)
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