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Identifying and Characterizing Virus/Host Interactions of RNA Viruses
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Identifying and Characterizing Virus/Host Interactions of RNA Viruses

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 4501

Special Issue Editor

Dr. Kevin Sokoloski

E-Mail Website
Guest Editor
Department of Microbiology & Immunology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
Interests: RNA viruses; RNA–protein complexes; RNA functions; host/pathogen interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The discovery of RNA virus/host interactions has been a valuable area of research for over a quarter of a century. Importantly, these efforts have led to a greater understanding of the underlying molecular biology of RNA viruses for bacterial, animal, and plant viruses. Advances in virus/host discovery approaches have led to an increased understanding of the molecular interactions responsible for the regulation of viral replication, gene expression, and the control of host antiviral responses. This Special Issue will cover recent advances in the identification of RNA virus/host interactions at the RNA–Protein and Protein–Protein levels, including novel discovery approaches, characterizations of the molecular and biological consequences of specific interactions, and connective meta-analyses of RNA virus interactomes.

Dr. Kevin Sokoloski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA virus
  • virus–host interactions
  • RNA–protein
  • protein–protein
  • interactome

Published Papers (1 paper)

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Research

10 pages, 1459 KiB  
Article
Effect of An 84-bp Deletion of the Receptor-Binding Domain on the ACE2 Binding Affinity of the SARS-CoV-2 Spike Protein: An In Silico Analysis
by Gábor Kemenesi, Gábor Endre Tóth, Dávid Bajusz, György M. Keserű, Gabriella Terhes, Katalin Burián, Safia Zeghbib, Balázs A. Somogyi and Ferenc Jakab
Genes 2021, 12(2), 194; https://doi.org/10.3390/genes12020194 - 29 Jan 2021
Cited by 3 | Viewed by 4164
Abstract
SARS-CoV-2 is a recently emerged, novel human coronavirus responsible for the currently ongoing COVID-19 pandemic. Recombination is a well-known evolutionary strategy of coronaviruses, which may frequently result in significant genetic alterations, such as deletions throughout the genome. In this study we identified a [...] Read more.
SARS-CoV-2 is a recently emerged, novel human coronavirus responsible for the currently ongoing COVID-19 pandemic. Recombination is a well-known evolutionary strategy of coronaviruses, which may frequently result in significant genetic alterations, such as deletions throughout the genome. In this study we identified a co-infection with two genetically different SARS-CoV-2 viruses within a single patient sample via amplicon-based next generation sequencing in Hungary. The recessive strain contained an 84 base pair deletion in the receptor binding domain of the spike protein gene and was found to be gradually displaced by a dominant non-deleterious variant over-time. We have identified the region of the receptor-binding domain (RBD) that is affected by the mutation, created homology models of the RBDΔ84 mutant, and based on the available experimental data and calculations, we propose that the mutation has a deteriorating effect on the binding of RBD to the angiotensin-converting enzyme 2 (ACE2) receptor, which results in the negative selection of this variant. Extending the sequencing capacity toward the discovery of emerging recombinant or deleterious strains may facilitate the early recognition of novel strains with altered phenotypic attributes and understanding of key elements of spike protein evolution. Such studies may greatly contribute to future therapeutic research and general understanding of genomic processes of the virus. Full article
(This article belongs to the Special Issue Identifying and Characterizing Virus/Host Interactions of RNA Viruses)
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