The Post-transcriptional Control of Gene Expressions
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "RNA".
Deadline for manuscript submissions: closed (25 September 2023) | Viewed by 311
Special Issue Editor
Interests: genetics; the post-transcriptional control of gene expression; microRNAs; long noncoding RNAs
Special Issue Information
Dear Colleagues,
The post-transcriptional control of gene expression is an important mechanism at the RNA level. This control is critical for the regulation of countless genes across human tissues and plays a role in cell physiology and in pathologies such neurodegenerative diseases and cancer. At any stage after transcription arises, RNA splicing, nuclear shuttling, and RNA stability are controlled by the post-transcriptional control of gene expression, as well as RNA processing, RNA transport, and post-transcriptional. RNA-binding proteins (RBPs) are proteins that interact with their target RNAs to form ribonucleoprotein complexes and control this post-transcriptional regulation of gene expression. Such complexes regulate almost every aspect of post-transcriptional processing such as pre-mRNA splicing, translational control, cleavage and polyadenylation, and RNA editing. RBPs can also control the post-transcriptional gene expression process by regulating the biogenesis and function of non-coding RNAs. Interestingly, RBPs are also required to make miRNAs and miRNA-controlled gene expressions. MicroRNAs or miRNAs are short non-coding RNAs, 18-22 nucleotides in length, with a purpose to act as key regulators of numerous biological processes through the post-transcriptional control of gene expression. Based on several investigations, a new post-transcriptional regulatory mechanism is represented by the lncRNAmiRNA-mRNA and circRNA-miRNA-mRNA-ceRNA networks, involved in the emergence and progression of various conditions in humans.
This Special Issue welcomes all the mechanisms that can serve as eukaryotes in the post-transcriptional control of gene expressions.
Dr. Bruna De Felice
Guest Editor
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