Next Article in Journal
Twenty-Five Years Experience on RET Genetic Screening on Hereditary MTC: An Update on The Prevalence of Germline RET Mutations
Previous Article in Journal
Genome-Wide Identification and Expression Profiles of Late Embryogenesis-Abundant (LEA) Genes during Grain Maturation in Wheat (Triticum aestivum L.)
Open AccessArticle

BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells

Oncogenomic and Epigenetic Unit, IRCSS Regina Elena National Cancer Institute, Via Elio Chianesi, 53-00144 Rome, Italy
Biology and Biotechnology Department “Charles Darwin”, Sapienza University of Rome, Piazzale Aldo Moro, 5-00185 Rome, Italy
Institute of Molecular Biology and Pathology, CNR, Via degli Apuli, 4-00185 Rome, Italy
Author to whom correspondence should be addressed.
Genes 2019, 10(9), 697;
Received: 24 June 2019 / Revised: 16 August 2019 / Accepted: 3 September 2019 / Published: 10 September 2019
(This article belongs to the Special Issue ALT: From Telomere Maintenance Mechanisms to Proposed Therapies)
BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. Here we demonstrate that BRCA2 deletion triggers TERRA hyperexpression and alternative lengthening mechanisms (ALT) in colon cancer cells in presence of telomerase activity. This finding opens the question if cancer patients bearing BRCA2 germline or sporadic mutation are suitable for anti-telomerase therapies, or how ALT activation could influence the short or long-term response to anti-PARP inhibitors or anti-G-quadruplex therapies. View Full-Text
Keywords: BRCA2 mutation; telomeres; ALT BRCA2 mutation; telomeres; ALT
Show Figures

Figure 1

MDPI and ACS Style

Pompili, L.; Maresca, C.; Dello Stritto, A.; Biroccio, A.; Salvat, E. BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells. Genes 2019, 10, 697.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

Back to TopTop