Next Article in Journal
Novel Mutations Found in Individuals with Adult-Onset Pompe Disease
Next Article in Special Issue
G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells
Previous Article in Journal
Identification and Selection of Reference Genes for Quantitative Transcript Analysis in Corydalis yanhusuo
Previous Article in Special Issue
Alternative Lengthening of Telomeres and Chromatin Status
Due to scheduled maintenance work on our core network, there may be short service disruptions on this website between 16:00 and 16:30 CEST on September 25th.
Review

ALT: A Multi-Faceted Phenomenon

Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK
*
Author to whom correspondence should be addressed.
Genes 2020, 11(2), 133; https://doi.org/10.3390/genes11020133
Received: 11 December 2019 / Revised: 17 January 2020 / Accepted: 22 January 2020 / Published: 27 January 2020
(This article belongs to the Special Issue ALT: From Telomere Maintenance Mechanisms to Proposed Therapies)
One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengthening of telomeres (ALT) pathway. Here, we review the phenotypes and molecular markers specific to ALT, and investigate the significance of telomere mutations and sequence variation in ALT cell lines. We also look at the recent advancements in understanding the different mechanisms behind ALT telomere elongation and finally, the progress made in identifying potential ALT-targeted therapies, including those already in use for the treatment of both hematological and solid tumors. View Full-Text
Keywords: alternative lengthening of telomeres; cancer; telomere-variant-repeat; break-induced telomere synthesis; therapy alternative lengthening of telomeres; cancer; telomere-variant-repeat; break-induced telomere synthesis; therapy
Show Figures

Figure 1

MDPI and ACS Style

Sommer, A.; Royle, N.J. ALT: A Multi-Faceted Phenomenon. Genes 2020, 11, 133. https://doi.org/10.3390/genes11020133

AMA Style

Sommer A, Royle NJ. ALT: A Multi-Faceted Phenomenon. Genes. 2020; 11(2):133. https://doi.org/10.3390/genes11020133

Chicago/Turabian Style

Sommer, Aurore, and Nicola J. Royle 2020. "ALT: A Multi-Faceted Phenomenon" Genes 11, no. 2: 133. https://doi.org/10.3390/genes11020133

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop