Mapping the Functional 3D Genome
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".
Deadline for manuscript submissions: closed (30 July 2021) | Viewed by 282
Special Issue Editors
Interests: genomics; chromosome conformation capture; mitosis; chromatin
Special Issue Information
Dear Colleagues,
Functional genomes require precise DNA interactions to enable gene expression in interphase, DNA duplication in S-phase and segregation in M-phase. Many protein complexes are involved in orchestrating and maintaining a functional genome throughout the cell cycle. We now know that beyond the linear genome sequence, the three-dimensional organization of the genome affects genome function and vice versa.
Improvements in genomic and microscopy techniques have allowed a detailed mapping of DNA–DNA as well as protein–DNA interactions. For instance, conformation capture with micro-C allows for an unprecedented genome-wide mapping of DNA interactions at a sub-kilobase resolution, and microscopy with OligoSTORM enables detailed visualization of interactions for large regions. Moreover, cross-over initiatives such as ATAC-PALM attempt to integrate both omics and microscopy approaches. Another set of newly developed techniques including Protect-seq, APEX and TSA-seq allows for the detection of sub-nuclear structures such as speckles and nucleoli.
In this Special Issue, we review recent advances in 3D nuclear mapping and the way it helps us understand the functioning of the nucleus.
Dr. Johan Gibcus
Dr. Kuniko Samejima
Guest Editors
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Keywords
- Genome
- Nucleus
- Microscopy
- Conformation capture
- Super resolution
- Three-dimensional
- Architecture
- Compartmentalization
- Spatial organization
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