Molecular Mechanisms of DNA Organization, Damage and Repair
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Genes & Environments".
Deadline for manuscript submissions: closed (1 November 2023) | Viewed by 385
Special Issue Editor
Special Issue Information
Dear Colleagues,
Eukaryotic genomes, despite their stability and well-regulated structural organization, they have always been subject to damage or lesions by chemical or physical factors. Till date, most of the damage observed is during erroneous replication. Several protein factors play important role in the surveillance of such error, leading to stalling of the cell cycle progression, repairing the defect or selectively proceed towards cell death if un-successful. Molecular and cellular processes, which include the sensing of DNA damage and signaling, the recruitment of DNA repair protein machinery onto the damage sites, and its functioning in addition to the release of damage sites, help to restore the integrity of the genome. There are five major DNA repair pathways, such as mismatch repair (MMR), base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR), and non-homologous end joining (NHEJ), which are active in almost all live forms. Apart from repair machinery and proof reading of the DNA sequence, higher order chromatin structural dynamics play an important role in making the lesion accessible.
In this issue, we invite authors to submit articles or reviews addressing aspects on advancement in the mechanisms of DNA damage, repair and mutagenesis and their impact on disease onset like cancer.
Dr. Somnath Paul
Guest Editor
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Keywords
- DNA damage & repair
- epigenetic regulation of DNA repair
- mutagenesis
- higher order chromatin organization and stability
- genomic instability
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