Next-Generation Sequencing for Pathogen Detection

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 57

Special Issue Editor


E-Mail Website
Guest Editor
Health Business Unit, Battelle Memorial Institute, Columbus, OH, USA
Interests: biosurveillance; infectious diseases; wastewater-based sequencing; epigenomic signature identification

Special Issue Information

Dear Colleagues,

Infectious disease diagnostics and surveillance rapidly evolved into molecular tests based on an analysis of nucleic acids and has been continuing to evolve with the advent of next-generation sequencing. Several techniques exist from gene-targeted amplicon sequencing to shotgun metagenomics for detecting and analysing pathogens present in clinical and environmental samples. Recently, sequencing-based methods for assessing the host response to pathogens has shown promise in detecting pathogens even before the microbes are at high enough concentration to be detectable. As methods advance, previous gaps which made sequencing-based pathogen surveillance and diagnostics cost prohibitive are being addressed and new challenges are emerging. This issue will focus on understanding the innovative advances in next-generation sequencing methods for the detection of pathogens in clinical and environmental samples above background noise.

Dr. Rachel R. Spurbeck
Guest Editor

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Keywords

  • next-generation sequencing
  • pathogen agnostic detection
  • infectious disease diagnostics
  • environmental pathogen surveillance

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Published Papers

This special issue is now open for submission.
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