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Gels
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Hydrogel Fibers
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Hydrogel Fibers

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 2159

Special Issue Editor

Dr. Yongxiang Luo

E-Mail Website
Guest Editor
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 3688, Nanhai Road, Nanshan District, Shenzhen 518060, China
Interests: 3D/4D bioprinting; hydrogel

Special Issue Information

Dear Colleagues,

Hydrogel fibers with size from nano to macro scales have attracted great interest for their applications in various fields including materials science, sensing and biomedical engineering. Owing to the features of biomimetic extracellular matrix, hydrogel fibers and hydrogel fibers based meshes and scaffolds showed the potential application for tissue engineering and regeneration medicine, such as wound healing and cartilage repair. Tailoring the multi-scale and hierarchical architecture of the hydrogel fibers enables the improved characteristics and novel application of the hydrogel fibers and fibrous meshes. For example, the hydrogel fibers with ordered orientation, core/shell and hollow channels structures showed the capability of improved mechanical properties and controlled drug delivery. The components, hierarchical structure, properties, and applications of the hydrogel fibers and fibrous meshes need more detailed discussion and understanding. Therefore, with this Special Issue of “hydrogel fibers”, a broad range of subjects, including the techniques for preparing hydrogel fibers and fibrous meshes and constructs, hierarchical structures and novel architectures of the hydrogel fibers, surface modification, improved properties, and the potential applications of the hydrogel fibers and fibrous meshes and scaffolds will be covered.     

Since it is impossible to cover all aspects of hydrogel fibers and fibers based three-dimensional meshes in one issue, this Special Issue will contain a few representative examples. It is hoped that the topics will stimulate new research and discoveries in the field of hydrogel fibers and fibrous meshes and broaden their applications.

Dr. Yongxiang Luo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel fibers
  • core-shell fibers
  • fibrous meshes
  • oriented structures
  • properties
  • modification
  • applications

Published Papers (1 paper)

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Research

17 pages, 3720 KiB  
Article
Application of “Magnetic Anchors” to Align Collagen Fibres for Axonal Guidance
by Devindraan S/O Sirkkunan, Farina Muhamad and Belinda Pingguan-Murphy
Gels 2021, 7(4), 154; https://doi.org/10.3390/gels7040154 - 27 Sep 2021
Cited by 2 | Viewed by 1680
Abstract
The use of neural scaffolds with a highly defined microarchitecture, fabricated with standard techniques such as electrospinning and microfluidic spinning, requires surgery for their application to the site of injury. To circumvent the risk associated with aciurgy, new strategies for treatment are sought. [...] Read more.
The use of neural scaffolds with a highly defined microarchitecture, fabricated with standard techniques such as electrospinning and microfluidic spinning, requires surgery for their application to the site of injury. To circumvent the risk associated with aciurgy, new strategies for treatment are sought. This has led to an increase in the quantity of research into injectable hydrogels in recent years. However, little research has been conducted into controlling the building blocks within these injectable hydrogels to produce similar scaffolds with a highly defined microarchitecture. “Magnetic particle string” and biomimetic amphiphile self-assembly are some of the methods currently available to achieve this purpose. Here, we developed a “magnetic anchor” method to improve the orientation of collagen fibres within injectable 3D scaffolds. This procedure uses GMNP (gold magnetic nanoparticle) “anchors” capped with CMPs (collagen mimetic peptides) that “chain” them to collagen fibres. Through the application of a magnetic field during the gelling process, these collagen fibres are aligned accordingly. It was shown in this study that the application of CMP functionalised GMNPs in a magnetic field significantly improves the alignment of the collagen fibres, which, in turn, improves the orientation of PC12 neurites. The growth of these neurite extensions, which were shown to be significantly longer, was also improved. The PC12 cells grown in collagen scaffolds fabricated using the “magnetic anchor” method shows comparable cellular viability to that of the untreated collagen scaffolds. This capability of remote control of the alignment of fibres within injectable collagen scaffolds opens up new strategic avenues in the research for treating debilitating neural tissue pathologies. Full article
(This article belongs to the Special Issue Hydrogel Fibers)
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