Hydrogel for Tissue Engineering and Biomedical Therapeutics (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 593

Special Issue Editor


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Guest Editor
Department of Chemical, Biological and Battery Engineering, Gachon University, Seongnam-si 13120, Gyeonggi-do, Republic of Korea
Interests: hydrogel; tissue engineering; drug delivery system; mechanobiology; stem cell fate control; hyaluronic acid hydrogel; click chemistry; electrospinning; three-dimensional cell culture
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Special Issue Information

Dear Colleagues,

This Special Issue, titled 'Hydrogel for Tissue Engineering and Biomedical Therapeutics (2nd Edition)', will provide a platform dedicated to exploring the transformative potential of hydrogels in tissue engineering and biomedical therapeutics. It will highlight the latest trends and breakthroughs in hydrogel research and promote a deeper understanding of their design, fabrication, and use. Hydrogels have shown exceptional promise in mimicking the cellular microenvironment for tissue regeneration and engineering. Their biocompatibility and tunable properties make them ideal candidates for targeted drug delivery, enabling more effective and less invasive therapeutic interventions.

We invite researchers and experts from various disciplines to contribute their insights to this Special Issue. Whether by detailing innovative synthesis methods, advanced characterization techniques, or novel applications, we will provide a comprehensive overview of this rapidly evolving field. By bringing together diverse perspectives, this Special Issue will serve as a compass to guide the future directions of hydrogel-based research and, ultimately, shape the landscape of tissue engineering and biomedical therapies.

You can read, download, and share the papers published in the first edition via the following link:
https://www.mdpi.com/journal/gels/special_issues/O82U18DA9B.

Dr. Hyun Jong Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • tissue engineering
  • biomedical therapeutics
  • biomimetic scaffolds
  • drug delivery
  • regenerative medicine
  • cell–material interactions

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Published Papers (1 paper)

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Research

27 pages, 13129 KB  
Article
Biofunctional Polyvinyl Alcohol/Xanthan Gum/Gelatin Hydrogel Dressings Loaded with Curcumin: Antibacterial Properties and Cell Viability
by María José Rivera, Alejandro Cament, Manuel Ahumada, Teresa Corrales, Verónica García, Jesús L. Pablos, Javiera Osorio, Giselle Ramos-González, Leslie Vargas-Saturno, Marcelo Ezquer and J. Andrés Ortiz
Gels 2025, 11(10), 764; https://doi.org/10.3390/gels11100764 - 23 Sep 2025
Viewed by 481
Abstract
This study explores the development of biocompatible hydrogel dressings incorporating curcumin as an alternative antibacterial agent. In this context, hydrogels were prepared using polyvinyl alcohol, xanthan gum, gelatin, and curcumin as a therapeutic component. FTIR spectroscopy confirmed the successful incorporation of curcumin into [...] Read more.
This study explores the development of biocompatible hydrogel dressings incorporating curcumin as an alternative antibacterial agent. In this context, hydrogels were prepared using polyvinyl alcohol, xanthan gum, gelatin, and curcumin as a therapeutic component. FTIR spectroscopy confirmed the successful incorporation of curcumin into the hydrogel matrix, while release profiles demonstrated sustained release. Mechanical testing indicated that xanthan gum reduced elongation and strength in hydrogels, while the combination of xanthan gum and gelatin increased stiffness without loss of elasticity. Curcumin had no major effect on the tensile and rheological properties, preserving the structural integrity of the hydrogels. The hydrogels demonstrated antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus ATCC strains, as well as multidrug methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. Biocompatibility was confirmed through viability assays with immortalized human keratinocytes (HaCaT) and adult human dermal fibroblasts (HDFa), showing no acute cytotoxic effects after 48 h of exposure. Their effective action against clinically relevant bacteria and high cytocompatibility position these hydrogels as promising candidates for infection management and antibiotic resistance mitigation in wound care applications. Full article
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