Functional Hydrogels for Advanced Health Monitoring Systems

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 319

Special Issue Editor


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Guest Editor
School of Life Sciences, Xi'an Jiaotong University, Xi’an 710049, China
Interests: stimuli-responsive polymers; hydrogels; wearables; health monitoring; colorimetric sensors; anti-counterfeiting; biosensors
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Special Issue Information

Dear Colleagues,

Hydrogels are transformative materials for next-generation health monitoring, offering unmatched biocompatibility, stimuli-responsive behavior, and tunable mechanical/chemical properties that enable seamless integration with biological tissues. This Special Issue in Gels seeks cutting-edge research and reviews on the design, synthesis, and functionalization of hydrogels specifically engineered for real-time physiological tracking and diagnostic applications. We welcome contributions exploring novel hydrogel architectures (e.g., double-network, nanocomposite, or supramolecular) with enhanced conductivity, self-healing, or adhesive properties. Dynamic sensing mechanisms leverage pH, temperature, biomarkers, pressure, and strain for monitoring metabolites (glucose and lactate), electrolytes, or vital signs (ECG, motion). Advanced fabrication techniques (3D bioprinting, microneedle arrays, and injectable formulations) enable non-invasive or minimally invasive deployment. Integration strategies for wearable/implantable sensors emphasize signal stability, biocompatibility, and power efficiency. Manuscripts addressing scalability, long-term stability in vivo, clinical validation, or AI-driven data analysis are encouraged. This Special Issue aims to bridge materials science with translational healthcare, accelerating the development of functional hydrogels for personalized diagnostics and proactive medicine.

Dr. Fei Han
Guest Editor

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Keywords

  • hydrogel
  • physiological signal monitoring
  • conductivity
  • self-healing
  • adhesive properties
  • sensors
  • wearable
  • diagnostic applications

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Published Papers (1 paper)

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Research

21 pages, 5897 KB  
Article
Development and Electrochemical Performance of a PANI-PA-PVA Hydrogel-Based Flexible pH Fiber Sensor for Real-Time Sweat Monitoring
by Shiqi Li, Chao Sun, Meihui Gao, Haiyan Ma, Longbin Xu and Xinyu Li
Gels 2025, 11(11), 853; https://doi.org/10.3390/gels11110853 (registering DOI) - 25 Oct 2025
Viewed by 156
Abstract
Real-time sweat pH monitoring offers a non-invasive window into metabolic status, disease progression, and wound healing. However, current wearable pH sensors struggle to balance high electrochemical sensitivity with mechanical compliance. Here we report a stretchable fiber-integrated pH electrode based on a polyaniline-phytic acid-polyvinyl [...] Read more.
Real-time sweat pH monitoring offers a non-invasive window into metabolic status, disease progression, and wound healing. However, current wearable pH sensors struggle to balance high electrochemical sensitivity with mechanical compliance. Here we report a stretchable fiber-integrated pH electrode based on a polyaniline-phytic acid-polyvinyl alcohol (PANI-PA-PVA) hydrogel, which combines mechanical elasticity with enhanced electrochemical performance for continuous sweat sensing. Freeze–thaw crosslinking of the hydrogel forms a porous interpenetrating network, facilitating rapid proton transport and stable coupling with dry-spun elastic gold fibers. This wearable device exhibits an ultra-Nernstian sensitivity of 68.8 mV pH−1, ultra-fast equilibrium (<10 s within the sweat-relevant acidic window), long-term drift of 0.0925 mV h−1, and high mechanical tolerance (gel stretch recovery up to 165%). The sensor maintains consistent pH responses under bending and tensile strains, yielding sweat pH measurements at the skin surface during running that closely match commercial pH meters (sweat pH range measured in test subjects: 4.2–5.0). We further demonstrate real-time wireless readouts by integrating elastic gold and Ag/AgCl fibers into a three-electrode textile structure. This PANI-PA-PVA hydrogel strategy provides a scalable material platform for robust, high-performance wearable ion sensing and skin diagnostics. Full article
(This article belongs to the Special Issue Functional Hydrogels for Advanced Health Monitoring Systems)
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