Current Directions and Prospects of Hydrogels for Biomedical Applications (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 728

Special Issue Editors


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Guest Editor
Biomed Center Innovation gGmbH, 95447 Bayreuth, Germany
Interests: hydrogels; biosensors; surface modification for bioapplication
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Physical Chemistry I, Department of Chemistry & Biology & Research Center of Micro and Nanochemistry and (Bio)Technology (Cμ), University of Siegen, 57076 Siegen, Germany
Interests: hydrogel sensing materials; bacteria detection; polymer brushes; stimulus-responsive polymers; cell release surfaces; nanobubbles, nanodroplets and nanocapsules; microparticle self-assembly
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Guest Editor
Biomaterials, Drug Delivery and Nanotechnology Unit, Centre for Biomedical and Biomaterials Research, University of Mauritius, MSIRI Building, Réduit 80837, Mauritius
Interests: biomaterials; nanotechnology; regenerative medicine; polymer engineering; cell–material interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels are interesting biomaterials due to their high swelling capacity, which allows them to hold and release materials at tailorable rates, as well as their excellent biocompatibility with minimal inflammatory responses. Even though the term ‘hydrogel’ was first coined in 1864, it was not until 1960 that these self-supporting 3D water-swollen viscoelastic polymer networks found their first application in the biomedical field, as reported in the seminal paper co-authored by Wichterle and Lim.

Single-component hydrogel systems have shown limitations due to either poor mechanical properties or insufficient cell-recognition moieties to facilitate cell adhesion and proliferation. To improve the performance of hydrogels in the biomedical field, new synthetic and analytical methods have been used to design more advanced smart and responsive (temperature, pH, light, ultrasound, enzyme, ionic strength, electrical, magnetic, etc.) hydrogels to better suit the targeted biomedical application.

For instance, the inclusion of nanomaterials into hydrogels led to the creation of a new generation of hydrogels known as nanocomposite hydrogels. Self-healing hydrogels have been designed for their own repair or to help in the healing of damaged tissues.

This Special Issue of Gels focuses on recent innovations related to hydrogels and showcases state-of-the-art original articles as well as comprehensive reviews in this rapidly evolving field.

Dr. Zhiyuan Jia
Prof. Dr. Holger Schönherr
Dr. Nowsheen Goonoo
Guest Editors

Manuscript Submission Information

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Keywords

  • hydrogels
  • stimuli-responsive materials
  • self-healing
  • nanocomposite
  • biomedical application

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Published Papers (1 paper)

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Review

15 pages, 731 KB  
Review
Novel Approaches for the 3D Printing of Collagen-Sourced Biomaterials Against Infectious and Cardiovascular Diseases
by Yugyung Lee and Chi H. Lee
Gels 2025, 11(9), 745; https://doi.org/10.3390/gels11090745 - 16 Sep 2025
Viewed by 583
Abstract
Collagen is a versatile material, and collagen in the human body strengthens the muscles and related organs, allowing good substances to be absorbed into the bloodstream while preventing the absorption of toxic substances. Thus, collagen has been broadly applied in regenerative medicine and [...] Read more.
Collagen is a versatile material, and collagen in the human body strengthens the muscles and related organs, allowing good substances to be absorbed into the bloodstream while preventing the absorption of toxic substances. Thus, collagen has been broadly applied in regenerative medicine and tissue engineering. A comprehensive framework for various collagen products has been created by integrating collagen resources with additive components. The application of 3D-bioprinting technologies for designing physiological models further allows for the introduction of enhanced preclinical testing tools that can contribute to successful elucidation of the mechanisms behind host–pathogen interactions, and subsequent prevention and treatment of various diseases. In this review, novel strategies for the 3D-printing production of collagen-sourced biomedical devices, as well as diverse applications customized with advanced artificial intelligence (AI) technologies, were thoroughly examined. Ongoing challenges, including the inherent limitations in the mechanical weakness of collagen-based bioinks, such as printability and stability, along with cell viability and bioavailability, and advanced strategies addressing those challenges, were also reviewed. An integration of 3D printing with collagen as a bioink is enormously efficient in biomedical applications, demonstrating its great potential for clinical translation against infectious diseases, including cardiovascular diseases. Full article
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