Advances in Functional Gel (3rd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 1063

Special Issue Editors


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Guest Editor

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Guest Editor
Institute for the Study of Nanostructured Materials, ISMN—CNR, Palermo, c/o Department of ChiBioFarAm, University of Messina, 98166 Messina, Italy
Interests: material chemistry; nanotechnology; sol–gel chemistry; polymer science; Hi-tech textiles; functional coatings; sustainability; stimuli-responsive polymers
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Guest Editor
1. Institute for the Study of Nanostructured Materials, ISMN—CNR, Palermo, Italy
2. Department of ChiBioFarAm, University of Messina, 98166 Messina, Italy
Interests: materials chemistry; green chemistry; nanotechnology; environmental remediation; advanced materials; filtration membranes; stimuli-responsive polymers; functional systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, due to the increasing demands of modern society for sustainability, environmental protection, and pollution prevention, there has been a growing global need for more efficient, eco-friendly, and long-life materials.

In this framework, it appears to be quite necessary to encompass a range of strategies that can help in the transition towards a circular economy by supporting the following:

  • A reduction in primary raw material consumption, fossil-based reagents and waste production;
  • The development of multifunctional products that can help in saving money and reducing pollution, by decreasing the number of products in our everyday life;
  • The maintenance of the final product performance over time by improving its resistance to external agents and wear from end users, thereby extending the product life cycle.

Using this reasoning, recent studies in materials chemistry have increasingly focused on the development of innovative and smart (multi)functional gel-based materials, which exhibit a wide range of valuable properties for applications across biomedical, sensing, textile, catalysis, construction, cultural heritage, blue growth, automotive, and environmental industrial sectors.

Additionally, nanotechnology has been shown to be a determinant in the rational design of these novel functional nanostructured gel formulations, leading to advanced nano-hybrid or nanocomposite gels, also useful as coatings for surface properties’ implementation, such as anti-vegetative or antibacterial, hydrophobic, anti-stain, fire-retardant, controlled drug release, molecule detection, protection, and mechanical resistance.

In this regard, gel technologies are receiving considerable attention for the design and development of functional hybrid organic and inorganic systems. These systems are based on host (or blended) polymeric matrices and opportune functional nanofillers, offering advantages such as low process temperature, no cytotoxicity, high final product homogeneity, hazardous solvent’s absence, high versatility, and stable binding to functional molecules or surfaces.

Furthermore, green and eco-friendly gel-based synthetic protocols can be established in combination with naturally derived polymers and bio-based or secondary raw materials, thereby resulting in new eco-friendly products that can be recycled and re-used.

Dr. Maria Rosaria Plutino
Dr. Silvia Sfameni
Dr. Giulia Rando
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart gel systems
  • nanohybrid gels
  • nanocomposite gels
  • innovative advanced gels
  • bio-based gel materials
  • sol–gel technique
  • functional gel coatings

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Published Papers (2 papers)

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Research

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15 pages, 14001 KB  
Article
Single-Step Engineered Gelatin-Based Hydrogel for Integrated Prevention of Postoperative Adhesion and Promotion of Wound Healing
by Xinyu Wu, Lei Sun, Jianmei Chen, Meiling Su and Zongguang Liu
Gels 2025, 11(10), 797; https://doi.org/10.3390/gels11100797 - 2 Oct 2025
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Abstract
Postoperative adhesion remains a major clinical challenge, often leading to chronic pain, functional disorders, and recurrent surgeries. Herein, we developed a multifunctional gelatin–polyphenol hydrogel (GPP20) featuring rapid gelation (within 5 min), strong tissue adhesion (lasting > 24 h under physiological conditions), and intrinsic [...] Read more.
Postoperative adhesion remains a major clinical challenge, often leading to chronic pain, functional disorders, and recurrent surgeries. Herein, we developed a multifunctional gelatin–polyphenol hydrogel (GPP20) featuring rapid gelation (within 5 min), strong tissue adhesion (lasting > 24 h under physiological conditions), and intrinsic wound healing capacity to achieve integrated prevention of postoperative adhesion. GPP20 was fabricated via dynamic crosslinking between gelatin and tea polyphenol, endowing it with injectability, self-healing, biodegradability, and excellent mechanical properties (shear stress of 14.2 N). In vitro studies demonstrated that GPP20 exhibited effective ROS scavenging (82% ABTS scavenging capability), which protects cells against oxidative stress, while possessing excellent hemocompatibility and in vivo safety. Notably, GPP20 significantly reduced postoperative cecum–abdominal wall adhesions through both physical barrier effects and modulation of inflammation and collagen deposition, demonstrating a comprehensive integrated prevention strategy. Furthermore, in full-thickness wound models, GPP20 accelerated tissue regeneration (85% wound closure rate on day 10) by promoting macrophage polarization toward the M2 phenotype and stimulating angiogenesis, thereby enhancing collagen deposition and re-epithelialization. Collectively, these findings demonstrate that GPP20 integrates anti-adhesion efficacy with regenerative support, offering a facile and clinically translatable strategy for postoperative care and wound healing. Full article
(This article belongs to the Special Issue Advances in Functional Gel (3rd Edition))
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Review

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30 pages, 1640 KB  
Review
Chitosan-Based Nanogels in Modern Drug Delivery: Focus on Protein and Gene Applications
by Muhammet Davut Arpa and Fatma Julide Akbuğa
Gels 2025, 11(9), 735; https://doi.org/10.3390/gels11090735 - 12 Sep 2025
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Abstract
Nanogels have attracted significant attention in recent years due to their high biocompatibility, controlled release capacity, sensitivity to environmental stimuli, and targeted transport characteristics as drug delivery systems. Chitosan, a natural polysaccharide, is a biopolymer widely used in nanogel formulations due to its [...] Read more.
Nanogels have attracted significant attention in recent years due to their high biocompatibility, controlled release capacity, sensitivity to environmental stimuli, and targeted transport characteristics as drug delivery systems. Chitosan, a natural polysaccharide, is a biopolymer widely used in nanogel formulations due to its positively charged structure, biodegradability, and modifiable functional groups. In this review, the therapeutic applications of chitosan-based nanogels are discussed thoroughly, especially emphasizing in the areas of protein/peptide, antigen, and gene transport. Production methods, chemical modification strategies, transport mechanisms to target cells, and the biological activities of these systems have been evaluated. Chitosan nanogels are promising carrier systems in wide range of areas, including gene therapy, immunotherapy, and the delivery of biological agents, owing to their significant characteristics such as intracellular targeting, endosomal escape, and sustained release. Further studies might enable the translation of these systems into clinical applications. Full article
(This article belongs to the Special Issue Advances in Functional Gel (3rd Edition))
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