Gel Biomaterials for Cancer Therapy and Biomedical Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 612

Special Issue Editors


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Guest Editor
Center for Engineering in Medicine & Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
Interests: biomedicine; cancer immunotherapy; immunotherapeutic biomaterials; microfluidic devices; gels

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Guest Editor
Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
Interests: quantitative cell mechanobiology; biomechanics; microfluidic devices for modeling physiological systems; nano/microtechnology; live cell imaging

Special Issue Information

Dear Colleagues,

Gel-based biomaterials represent a versatile and transformative class of materials for advancing cancer therapy and other biomedical applications. Their unique properties—such as tunable mechanical strength, biocompatibility, and capability to mimic natural extracellular matrix environments—make them invaluable in the development of innovative therapeutic platforms. From injectable scaffolds that support targeted cell and drug delivery to 3D ex vivo models to study tumor biology or screen therapeutic drugs, biomaterials offer a promising future in a diverse array of biomedical applications.

This Special Issue focuses on the design, synthesis, and application of gel biomaterials tailored for cancer therapy and broader biomedical innovations. We invite contributions that explore novel gel formulations, material–cell interactions, and translational approaches for enhancing therapeutic efficacy. Topics may include, but are not limited to, the following:

  • Hydrogels for controlled drug or cell delivery;
  • Gel-based platforms for immunotherapy or tissue regeneration;
  • Injectable gels for minimally invasive cancer treatments;
  • Three-dimensional gel systems for in vitro modeling of distinct microenvironments;
  • Smart gels responsive to biological or environmental cues.

By gathering cutting-edge research in this field, this Special Issue aims to highlight advancements that bridge the gap between materials science and clinical applications. Submissions are encouraged from interdisciplinary teams that span biomaterials science, cancer research, bioengineering, and translational medicine.

Dr. Natalie K. Livingston
Dr. Kimberly M. Stroka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gel biomaterials
  • hydrogels
  • cancer therapy
  • drug delivery systems
  • tumor microenvironment
  • immunotherapy
  • injectable gels

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Published Papers (1 paper)

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Review

56 pages, 3092 KB  
Review
Hydrogels in the Immune Context: In Vivo Applications for Modulating Immune Responses in Cancer Therapy
by Mara R. Lanis, Sujin Kim and Jonathan P. Schneck
Gels 2025, 11(11), 889; https://doi.org/10.3390/gels11110889 - 4 Nov 2025
Viewed by 333
Abstract
In response to growing clinical demands for more targeted and effective immunotherapies to treat cancer, biomaterial-based strategies have emerged as powerful tools for locally regulating immune responses. Among these, hydrogels, a class of biocompatible and tunable polymeric networks, are increasingly being leveraged for [...] Read more.
In response to growing clinical demands for more targeted and effective immunotherapies to treat cancer, biomaterial-based strategies have emerged as powerful tools for locally regulating immune responses. Among these, hydrogels, a class of biocompatible and tunable polymeric networks, are increasingly being leveraged for their high versatility and adaptability for creating tailored immune environments. By enabling controlled delivery of immune cues and direct cellular engineering, hydrogels utilized in vivo can precisely regulate both innate and adaptive immune responses while minimizing systemic toxicity. In this review, we outline essential hydrogel design features necessary for in vivo functionality including injectability, degradation kinetics, and immune-specific functionalization. Building on these principles, we explore how hydrogels have been employed to enhance T cell activation and dendritic cell maturation and guide macrophage reprogramming. Beyond cellular modulation, we further examine the use of hydrogels for cytokine and immunoregulatory agent delivery, tumor microenvironment remodeling, and the creation of tertiary-like lymphoid structures. Finally, we review recently completed and ongoing clinical trials of hydrogels in the cancer immunotherapy space. Together, these insights underscore the growing potential of in vivo hydrogel systems as immuno-interactive platforms capable of reshaping immune responses across diverse disease contexts. Full article
(This article belongs to the Special Issue Gel Biomaterials for Cancer Therapy and Biomedical Applications)
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