Chronic Liver Disease and Comorbidities

Dear colleagues,

Chronic liver diseases are complex, with multiple causes, and affect approximately 1.5 billion individuals worldwide. In recent decades, advances in the diagnostic and therapeutic management of viral hepatitis have led to improvements in the morbidity and mortality rates associated with chronic liver diseases. Thus, the death rate decreased from 21 deaths per 100,000 inhabitants in 1990, to 16.5 cases per 100,000 inhabitants in 2019. Additionally, the proportion of diseases that can evolve into chronic liver disease has changed. Currently, the dominant etiology is represented by nonalcoholic fatty liver disease (NAFLD): 59% of cases.

One clinical challenge is presented by the association of chronic liver disease with other comorbidities and the establishment of optimal therapeutic management. These conditions can have a negative impact on both the quality of life and the life expectancy of these patients. An example is the need for anticoagulant treatment in a patient with chronic liver disease and the impairment of biological markers of coagulation. To ensure optimal therapeutic management of these patients, a multidisciplinary team is necessary.

We invite the submission of articles reporting on this topic. We are particularly interested in reviews or original articles that provide an overview of diagnostic and treatment protocols individualized for patients with chronic liver disease and various comorbidities. Additionally, articles presenting new research directions or future perspectives are welcome.

Dr. Gina Gheorghe
Guest Editor

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