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Special Issue "Non-CpG Methylation"
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2614
Special Issue Editors
2. Pasteur Institute Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy
Interests: regulation of DNA methylation and demethylation processes in eukaryotic cells; DNA methylation, modulation of gene expression and cell differentiation; molecular mechanisms of the gene therapy by small fragment homologous replacement (SFHR); molecular genetics of cystic fibrosis and of CFTR-related disorders and study of the genotype/phenotype relationship in this diseases; theratyping of cystic fibrosis; functional characterization of CFTR (cystic fibrosis transmembrane conductance regulator) and ENaC (epithelial sodium channel) genes in physiologic and pathologic conditions; molecular diagnostic methodologies and pathogenetic mechanisms underlying cystic fibrosis, CFTR-related disorders, atherosclerosis, alcohol addiction and neurological disorders; setup and automation of mutational search methodologies
Interests: DNA methylation; epigenetics; nutrition; methylation metabolism; environmental epigenetics; neuroepigenetics; gene expression and chromatin Biology; Bisulfite sequencing; Real-Time PCR; Alzheimer’s disease; aging research; Beta amyloid; neuroscience; neurobiology; neurodegenerative diseases; neurophysiology; neurodegeneration; neurobiology and brain physiology; animal models; cell culture; neurobiochemistry; methylation
Special Issue Information
The DNA methylation, consisting in the presence of a methyl group (-CH3) on the carbon 5’ of the cytosine, represents the most known and most studied epigenetic mark, able to regulate the mRNA expression of the associated genes. Despite the very impressive bulk of studies related to DNA methylation mechanisms, dynamics, function and its physiological and even pathogenetic role, the scientific community has been stuck for years on the concept that >90% of DNA methylation in mammals occurs on the cytosines followed by a guanine, i.e. the CpG moieties. The possibility that DNA methylation at cytosines followed by other nucleotides, the so-called non-CpG methylation (or “CpN”, including CpA, CpT, CpC), remained confined to a small proportion of cytosines, considered non-functionally significant, except for embryonic tissues and stem cells. In the recent years, however, many evidences raised the possibility that the non-CpG methylation in adult and somatic tissues was underestimated due to technical biases and supported the idea that it could have functional role in driving gene expression.
The present Special Issue is aimed at collecting research articles and reviews that can draw the state-of-the-art on the role of non-CpG methylation in mammal cells, its dynamic regulation, structural patterning and role in pathogenic mechanisms.
Prof. Dr. Marco Lucarelli
Prof. Dr. Andrea Fuso
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.