Advances in Profiling and Deciphering the Functional Role of RNA Modifications
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 5924
Special Issue Editors
Interests: gene expression; genomics; bioinformatics and computational biology; gene regulation; bioinformatics; epigenetics; transcriptomics; computational biology; transcription; NGS data analysis; DNA methylation; RNA methylation; epitranscriptome; RNA metabolism; gene expression and chromatin biology; chromatin; methylation; epigenomics
Interests: DNA and RNA editing
Special Issue Information
Dear Colleagues,
In parallel to the surge of studies in the field of epigenetics, dozens of epitranscriptional RNA modifications were identified in the last decades. Research in the epitranscriptome field has benefited from the recent development of methods to better quantify these marks and profile them at the genome level. Yet, despite a number of studies have confirmed the prominent role of some of these marks in shaping the fate of marked RNAs, we are only at the beginning of deciphering the effects of these modifications. Multiple effectors were identified that contribute to installing, removing, and reading these marks. However, the detailed activity of individual effectors and their joint contribution to the establishment of specific epitranscriptional patterns are yet to be deciphered. As the field progresses, novel methods are awaited for the specific, quantitative, and high-resolution profiling of these marks. Eventually, these maps will start revealing the functional role of individual modifications in physiological and disease conditions and whether the ensemble of modifications decorating various transcript types defines a new epitranscriptional code.
In this Special Issue, we will consider outstanding reviews, research, or method manuscripts on the following topics:
- Experimental methods to profile RNA modifications
- Computational methods for the analysis of epitranscriptional data
- Insights on the functional role of epitranscriptional marks and their effectors
- Prevalence and functional role of epitranscriptional marks in diseases
- The crosstalk between epitranscriptional marks
- The crosstalk between the epitranscriptome and the epigenome
Dr. Mattia Pelizzola
Dr. Silvo Conticello
Guest Editors
Manuscript Submission Information
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