Special Issue "Wine and Vine Components and Health"

A special issue of Diseases (ISSN 2079-9721).

Deadline for manuscript submissions: closed (30 October 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Norbert Latruffe

Université de Bourgogne, 21000 Dijon, France
Website | E-Mail
Interests: bio-active polyphenols; resveratrol; inflammation; bio-availability; cancer; pathologies prevention
Norbert Latruffe obtained his PhD 1977, and has been appointed in 1989 full Professor in Biochemistry at the University of Burgundy-Dijon France, and as head of the Laboratory of Molecular and Cellular Biology to 2006. Then, he was in charge of the team of Biochemistry of Metabolism and Nutrition in the INSERM research center, UMR 866 of Dijon until end of 2011. Since 2013 he is senior Professor at the laboratory of Biochemistry at the faculty of life science. In 1998 he launched a new challenge on the preventing role of vine polyphenols especially resveratrol, against age-related pathologies: cancer, inflammation cardiovascular. He was one of the first to explore resveratrol transport and metabolism (2004), its pro-apoptotic properties (2004), discovered a new resveratrol signalling pathway through micro RNA’s modulation (2010). In 2014 he showed a preventive effect of wine polyphenols towards colon cancer in mice model. He organized several and workshop on wine and health. Recently he served as editor or co-editor of «Molecules» two special issues: Natural products and inflammation (2016) and Improvement of resveratrol efficacy (2017). To date, he published near 170 international papers and has given more than invited 140 lectures. In 2017 he conducted the edition of a book deal on wine and mediterranean diet (EUD editor, Dijon). N. Latruffe is (or past) expert of several evaluation councils and is member of the orientation council of the prestigious UNESCO Chair «heritage and traditions of wine ». He also awarded several distinctions.
Guest Editor
Dr. Jean-Pierre Rifler

Haute Côte d’Or hospital center, F-21350, France
Website | E-Mail
Interests: wine and health; cardiovascular protection; wine polyphenols; Mediterranean nutrition and health
Jean-Pierre Rifler is emergency physician at the Haute Côte d’Or hospital center, F-21350, France. He become passioned of wine. After his obtained a diploma of Oenolog technician in 1988, he prepared his medical doctor thesis in 1994 on wine and health, especially on the cardiovascular protection by the red wine polyphenols. Since this date, in parallel to his professional activities, he collaborates with scientists in Burgundy in the aim to promote the beneficial effects of a regular and moderated consumption of wine. He managed thesis of medical doctors and set-up clinical protocols to validate the secondary prevention for post-infarcted patients by wine in 2012. This important work has been published in collaboration with Pr Norbert Latruffe, co-guest editor of this present issue, as follow «A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients’’ by Rifler JP., et al., Molecular Nutrition and Food Research 2011. vol. 55 pp1-7». Dr Jean-Pierre Rifler also published numerous specialized papers and his periodically invited in congresses and organizations such as in WAC (Wine Active Compounds), Beaune 2011; or at 5è ICPH (International conference on polyphenols on health), Sitges (Barcelona), 2011. He is co-funder of the Mediterranean Nutrition and Health association which organized a colloquium in Hyères (Provence) in 2016 on Wine, Mediterranean Nutrition and Health. By the way Dr Jean-Pierre Rifler is well known for having initiated the french programme on heart defribrillators in public space to save lifes.

Special Issue Information

Dear Colleagues,

While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis, an adaptable plant, thanks to a large variety of strains; wine is an alchemie with unique properties; a rich and original composition in terms of polyphenols, and well known anti-oxidants. This explains why wine and health are closely linked to nutrition.

In terms of biochemical mechanisms, vine like other plants produce numerous non-energy compounds, called secondary metabolites (e.g., flavonoids, polyphenols), in order to adapt their defenses against often unfavorable environment (biotic and non-biotic stresses), Interestingly, in humans and in the animals kingdom these microconstituents provide similar valuable bioactive properties for essential cell and physiological function (signaling, gene regulation, prevention of acquired or infectious disease, etc). These compounds have been selected through evolution and are generally preserved in all living beings. For instance, resveratrol that plays an essential role in vine plants as elicitor of the natural defenses has been shown to be a protector of health in humans. It could delay, or even block, the appearance of predominant diseases such as atherosclerosis by protecting low-density lipoproteins from the oxidation, but also diabetes and cancer.

Grape, fresh or dried, is a widely consumed fruit by large human populations, as also its by-products, like grape juice and wine, even extracts of vine leaves and shoot use. They contain vast and highly varied quantities of polyphenols as protective micronutrient. Wine, provide unique polyphenols: for instance, resveratrol, procyanidines and monophenols such as hydroxytyrosol and tyrosol. The research supports the idea that wine, a natural biological product, if consumed regularly, but without excess, possesses preventive properties, not only its well-known properties against vascular diseases (illustrated by the so-called French paradox) but also may prevent infections, decrease inflammation, delay neurodegenerative diseases. The question about cancer is still open.

Despite the huge amount of data on this topic, there is still gray areas and uncomplete knowledge. This is why the objective of this issue is to bring wine to a better view especially through the policy makers, the medical world and the vectors of image in order to explain the rational and the philosophy with respect to ethics and the public health.

The focus of this special issue on wine and vine components and health of the journal “Diseases” will includes the effects of wine on human physiology (cardiovascular, aged-linked disorders and s.o.); the effects of polyphenols as wine anti-oxidants and as signaling molecules; and from a humanity point of view, the tasting properties of wine.

Manuscripts (primary articles or review) providing new data and new concepts related to the following keys words are welcome: i.e. wine, vine and grape components including vitamins, minerals, ethanol and polyphenols such as resveratrol, and flavonoids; their bio-availability and metabolism; their effect on pathologies such as aging, longevity, cardiovascular, diabetes, cancer, obesity, inflammation, neurodegenerescence, cognition loss, pain, infection, skin problems, altered physical activity and s.o.

Prof. Dr. Norbert Latruffe
Dr. Jean-Pierre Rifler
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wine
  • vine and grape components
  • vitamins
  • minerals
  • ethanol
  • polyphenols
  • resveratrol
  • flavonoids
  • bio-availability
  • metabolism
  • hathologies
  • aging
  • longevity
  • cardiovascular
  • diatetes
  • cancer
  • obesity
  • inflammation
  • neurodegenerescence
  • cognition loss
  • pain
  • infection
  • skin problems
  • altered physical activity

Published Papers (4 papers)

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Research

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Open AccessFeature PaperArticle Wine and Olive Oil Phenolic Compounds Interaction in Humans
Received: 19 July 2018 / Revised: 24 August 2018 / Accepted: 27 August 2018 / Published: 1 September 2018
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Abstract
Extra virgin olive oil (EVOO) and red wine (RW) are two basic elements that form part of the so-called Mediterranean diet. Both stand out because of their high phenolic compound content and their potential related health benefits. The present study is focused on
[...] Read more.
Extra virgin olive oil (EVOO) and red wine (RW) are two basic elements that form part of the so-called Mediterranean diet. Both stand out because of their high phenolic compound content and their potential related health benefits. The present study is focused on the metabolic disposition of resveratrol (RESV), tyrosol (TYR), and hydroxytyrosol (HT) following the consumption of EVOO, RW, and a combination of both. In this study, 12 healthy volunteers consumed a single dose of 25 mL of EVOO, 150 mL of RW, and a combination of both in a crossover randomized clinical trial. Urinary recovery of RESV, TYR, and HT was analysed in urine samples collected over a 6-h period following the intake of each treatment. Higher HT levels were observed following EVOO compared to RW (3788 ± 1751 nmols and 2308 ± 847 nmols respectively). After the combination of EVOO and RW, the recovery of TYR and HT metabolites increased statistically compared to their separate consumption (4925 ± 1751 nmols of TYR and 6286 ± 3198 nmols of HT). EVOO triggered an increase in glucuronide conjugates, while RW intake raised sulfate metabolites. Marginal effects were observed in RESV increased bioavailability after the combination of RW with the fat matrix provided by EVOO. Full article
(This article belongs to the Special Issue Wine and Vine Components and Health)
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Open AccessArticle Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin
Received: 21 June 2018 / Revised: 19 July 2018 / Accepted: 20 July 2018 / Published: 22 July 2018
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Abstract
In the prevention of neurodegeneration associated with aging and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), neuronal differentiation is of interest. In this context, neurotrophic factors are a family of peptides capable of promoting the growth, survival, and/or differentiation of both developing and immature
[...] Read more.
In the prevention of neurodegeneration associated with aging and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), neuronal differentiation is of interest. In this context, neurotrophic factors are a family of peptides capable of promoting the growth, survival, and/or differentiation of both developing and immature neurons. In contrast to these peptidyl compounds, polyphenols are not degraded in the intestinal tract and are able to cross the blood–brain barrier. Consequently, they could potentially be used as therapeutic agents in neurodegenerative pathologies associated with neuronal loss, thus requiring the stimulation of neurogenesis. We therefore studied the ability to induce neuronal differentiation of two major polyphenols present in the Mediterranean diet: resveratrol (RSV), a major compound found in grapes and red wine, and apigenin (API), present in parsley, rosemary, olive oil, and honey. The effects of these compounds (RSV and API: 6.25–50 µM) were studied on murine neuro-2a (N2a) cells after 48 h of treatment without or with 10% fetal bovine serum (FBS). Retinoic acid (RA: 6.25–50 µM) was used as positive control. Neuronal differentiation was morphologically evaluated through the presence of dendrites and axons. Cell growth was determined by cell counting and cell viability by staining with fluorescein diacetate (FDA). Neuronal differentiation was more efficient in the absence of serum than with 10% FBS or 10% delipidized FBS. At concentrations inducing neuronal differentiation, no or slight cytotoxicity was observed with RSV and API, whereas RA was cytotoxic. Without FBS, RSV and API, as well as RA, trigger the neuronal differentiation of N2a cells via signaling pathways simultaneously involving protein kinase A (PKA)/phospholipase C (PLC)/protein kinase C (PKC) and MEK/ERK. With 10% FBS, RSV and RA induce neuronal differentiation via PLC/PKC and PKA/PLC/PKC, respectively. With 10% FBS, PKA and PLC/PKC as well as MEK/ERK signaling pathways were not activated in API-induced neuronal differentiation. In addition, the differentiating effects of RSV and API were not inhibited by cyclo[DLeu5] OP, an antagonist of octadecaneuropeptide (ODN) which is a neurotrophic factor. Moreover, RSV and API do not stimulate the expression of the diazepam-binding inhibitor (DBI), the precursor of ODN. Thus, RSV and API are able to induce neuronal differentiation, ODN and its receptor are not involved in this process, and the activation of the (PLC/PKC) signaling pathway is required, except with apigenin in the presence of 10% FBS. These data show that RSV and API are able to induce neuronal differentiation and therefore mimic neurotrophin activity. Thus, RSV and API could be of interest in regenerative medicine to favor neurogenesis. Full article
(This article belongs to the Special Issue Wine and Vine Components and Health)
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Graphical abstract

Open AccessArticle Grape Pomace: Antioxidant Activity, Potential Effect Against Hypertension and Metabolites Characterization after Intake
Received: 13 June 2018 / Revised: 4 July 2018 / Accepted: 6 July 2018 / Published: 6 July 2018
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Abstract
Observational studies indicate that the intake of polyphenol-rich foods improves vascular health, thereby significantly reducing the risk of hypertension and cardiovascular disease (CVD). Therefore, the aim of this study was to analyse the remained potential of grape by-products from important Rhône Valley red
[...] Read more.
Observational studies indicate that the intake of polyphenol-rich foods improves vascular health, thereby significantly reducing the risk of hypertension and cardiovascular disease (CVD). Therefore, the aim of this study was to analyse the remained potential of grape by-products from important Rhône Valley red wine cultivars: Grenache, Syrah, Carignan, Mourvèdre and Alicante. For that, six different extracts from grape pomaces, selected by their antioxidant activity, were studied in vivo during six weeks with spontaneously hypertensive rats (SHR). Extracts used in SHR1, SHR2 and SHR6 groups presented a « rebound effect » on systolic blood pressure, whereas the other extracts do not change it significantly. The bioavailability of Grenache (GRE1) (EA70) seed pomace extract (SHR1 group), Mouvendre (MOU) (EA70) skin pomace extract (SHR5 group) and Alicante (ALI) (EA70) skin pomace extract (SHR6 group) was studied by High Performance Liquid Chromatography with Photodiode Array detector and Electrospray Ionization Mass Spectrometer (HPLC-PDA-ESI-MSn) in urine, plasma and tissues to search differences on the metabolism of the different extracts intake. Full article
(This article belongs to the Special Issue Wine and Vine Components and Health)
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Review

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Open AccessFeature PaperReview Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases
Received: 12 July 2018 / Revised: 4 August 2018 / Accepted: 6 August 2018 / Published: 8 August 2018
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Abstract
Introduction: Moderate wine consumption is a characteristic of the Mediterranean diet. Studies around the world have shown a beneficial effect of moderate alcohol intake, especially wine, on health. This review aims to critically summarise the most recent studies that investigate the beneficial effects
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Introduction: Moderate wine consumption is a characteristic of the Mediterranean diet. Studies around the world have shown a beneficial effect of moderate alcohol intake, especially wine, on health. This review aims to critically summarise the most recent studies that investigate the beneficial effects of moderate wine intake on human health. Methods: The PubMed database was comprehensively searched to identify trials published from 2013 to 2018 that investigated the association between moderate wine consumption and health. Results: The most recent studies confirm the valuable role of moderate wine consumption, especially red wine, in the prevention and treatment of chronic diseases such as cardiovascular disease, metabolic syndrome, cognitive decline, depression, and cancer. In the meantime, recent studies also highlight the beneficial role of red wine against oxidative stress and in favour of desirable gut bacteria. The beneficial role of red wine has been attributed to its phytochemical compounds, as highlighted by clinical trials, where the effect of red wine has been compared to white wine, non-alcoholic wine, other alcoholic drinks, and water. Conclusions: Moderate wine intake, at 1–2 glasses per day as part of the Mediterranean diet, has been positively associated with human health promotion, disease prevention, and disease prognosis. Full article
(This article belongs to the Special Issue Wine and Vine Components and Health)
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