Advanced Computational Methods and Multiphysics Modeling in Bioengineering and Complex Systems

A special issue of Computation (ISSN 2079-3197). This special issue belongs to the section "Computational Engineering".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 499

Editors


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Guest Editor
Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, Serbia
Interests: computer simulations; machine learning; numerical analysis; high-performance computing; reinforcement learning

E-Mail Website
Guest Editor
Institute for Information Technologies, University of Kragujevac, 34000 Kragujevac, Serbia
Interests: computer simulations; numerical analysis; fluid computing

Special Issue Information

Dear Colleagues,

This Special Issue invites original research and review articles that focus on the development, analysis, and application of advanced computational methods to complex multiphysics and multiscale systems. We seek contributions that showcase advancements in numerical analysis and diverse computer simulations. We welcome submissions covering a broad spectrum of numerical discretization techniques, including, but not limited to, the Finite Element Method (FEM), Lattice Boltzmann Method (LBM), Finite Volume Method (FVM), Finite Difference Method (FDM), and various meshless methods (e.g., Radial Basis Functions).

A primary focus of this issue is coupled multiphysics problems, particularly within bioengineering and biomedicine. We are interested in research applying computational methods to model phenomena such as Fluid–Structure Interaction (FSI) in cardiovascular or respiratory systems, thermo-fluid dynamics and bioheat transfer for clinical applications, electro-mechanical coupling in cardiac and neural tissues, and porous medium models for tissue perfusion and drug delivery.

Furthermore, we strongly encourage papers that leverage emerging data-driven paradigms to enhance traditional modeling and simulation. This includes the use of Surrogate Modeling, Neural Networks, and Evolutionary Computation for model reduction, optimization, and parameter estimation. Submissions exploring the mathematical foundations and practical application of Physics-Informed Neural Networks (PINNs) to solve biological governing equations are also relevant. This Special Issue aims to be a comprehensive resource representing the state of the art in computational innovations.

Dr. Bogdan Milićević
Dr. Aleksandar Nikolić
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Computation is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • computational methods
  • numerical analysis
  • multiphysics modeling
  • bioengineering
  • biomedicine
  • finite element method (FEM)
  • lattice Boltzmann method (LBM)
  • finite volume method (FVM)
  • discontinuous Galerkin methods
  • computer simulations
  • surrogate modeling
  • neural networks
  • physics-informed neural networks (PINNs)
  • evolutionary computation

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Published Papers (1 paper)

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18 pages, 7382 KB  
Article
Computational Investigation of Friction Stir Processing of Ti-6Al-4V Alloy for Biomedical Applications Using FEM and Taguchi Design
by Nebojša Zdravković, Dragan S. Džunić, Živana Jovanovic Pešić and Dalibor Nikolić
Computation 2026, 14(7), 150; https://doi.org/10.3390/computation14070150 - 30 Jun 2026
Viewed by 147
Abstract
Friction stir processing (FSP) is an advanced solid-state surface modification technique for biomedical titanium alloys. This study presents a computational investigation of FSP applied to Ti-6Al-4V alloy through three-dimensional finite element modeling and Taguchi-based statistical optimization. A Taguchi L9 orthogonal array evaluated rotational [...] Read more.
Friction stir processing (FSP) is an advanced solid-state surface modification technique for biomedical titanium alloys. This study presents a computational investigation of FSP applied to Ti-6Al-4V alloy through three-dimensional finite element modeling and Taguchi-based statistical optimization. A Taguchi L9 orthogonal array evaluated rotational speed (400–1000 rpm), traverse speed (50–100 mm/min), shoulder diameter (6–18 mm), and pin diameter (2–6 mm), reducing the required simulations from 81 (full factorial) to nine (88.9% reduction). A calibrated friction model (μ = 0.35/0.25/0.20 for 400/800/1000 rpm, F = 6000 N) yielded maximum temperatures of 870–1384 °C; all predicted temperatures remained below the melting point of Ti-6Al-4V (1660 °C). These values are consistent with experimentally reported ranges for FSW/FSP of Ti-6Al-4V. Traverse speed is the dominant parameter (ANOVA contribution: 63.1%, F = 10.44), followed by rotational speed (26.7%) and shoulder diameter (4.1%). Simulation 3 (400 rpm, 100 mm/min, Ds = 18 mm, T_max = 870 °C) appears to be the most promising thermal condition for preserving the fine-grained α + β microstructure, as it remains below the β-transus temperature (980 °C) throughout the processed zone. Full article
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