Advanced Sensing Materials for Disease, Health and Environment Analysis

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Materials for Chemical Sensing".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1271

Special Issue Editors


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Guest Editor
Institute of Biomedical Engineering, College of Life Sciences, Qingdao University, Qingdao 266071, China
Interests: two-dimensional materials; nanomaterials; sensing; environmental monitoring; diagnostics and therapy

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Guest Editor
Tianjian Laboratory of Advanced Biomedical Sciences, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
Interests: CRISPR; biosensing; gene editing; mitochondrial DNA; single-nucleotide variation

Special Issue Information

Dear Colleagues,

In an era of escalating global health crises and environmental degradation, there is a critical demand for technologies that can sensitively detect pathogens, pollutants, and biomarkers. The rise of pandemics and antimicrobial resistance highlights the need for innovative sensing platforms that provide rapid and reliable diagnostics. These technologies are essential for protecting public health, enabling early disease intervention, and ensuring real-time monitoring to mitigate ecological risks. Advanced materials exceed the limitations of traditional detection systems. Utilizing nanoscale engineering, adjustable electronic properties, and high surface-to-volume ratios, these materials enable highly sensitive and selective sensors. Their ability to detect trace-level analytes—from individual molecules in biomedical diagnostics to ultrafine particles in air and water—positions them as key tools for addressing global challenges.

Key materials driving innovation include two-dimensional nanomaterials (like graphene and MXenes), quantum dots, metal–organic frameworks (MOFs), and bio-inspired polymers. Graphene’s exceptional conductivity makes it ideal for wearable biosensors that monitor glucose and cytokines in real-time, while MOFs effectively capture volatile organic compounds and greenhouse gasses. Plasmonic nanoparticles enhance optical sensing for early detection of cancer biomarkers, and advancements in nanocomposites allow simultaneous detection of multiple targets in complex matrices. Affordable, scalable devices are essential for widespread adoption, supported by sustainable synthesis methods such as green chemistry and roll-to-roll manufacturing to minimize ecological impacts. Additionally, integrating these materials with IoT platforms and AI-driven analytics can transform point-of-care diagnostics and environmental monitoring, providing communities with actionable insights.

We welcome submissions that explore the development, characterization, and application of advanced materials for ultrasensitive detection systems. Topics of interest include, but are not limited to, nanomaterial-based biosensors, eco-friendly fabrication techniques, lab-on-a-chip devices, and AI-integrated sensors for disease diagnosis, health monitoring, and environmental analysis. We particularly encourage interdisciplinary studies that address scalability, selectivity, and practical field applicability.

Dr. Xinsheng Wang
Dr. Kaixiang Zhang
Guest Editors

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Keywords

  • biosensors
  • chemical sensors
  • transistor sensors
  • semiconductor
  • surface-enhanced raman scattering (SERS)
  • flexible or wearable devices
  • nanomaterials
  • two-dimensional materials
  • micro/nano fabrication technology

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Published Papers (1 paper)

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Research

16 pages, 1334 KB  
Article
Development of a Paper-Based Electrochemical Immunosensor for Cardiac Troponin I Determination Using Gold Nanoparticle-Modified Screen-Printed Electrodes
by Mayra Asevedo Campos de Resende, Ana Elisa Ferreira Oliveira, Thaís Cristina de Oliveira Cândido, Daniela Nunes da Silva, Scarlat Ohanna Dávila da Trindade, Lucas Franco Ferreira and Arnaldo César Pereira
Chemosensors 2025, 13(11), 383; https://doi.org/10.3390/chemosensors13110383 - 31 Oct 2025
Cited by 1 | Viewed by 1055
Abstract
Acute Myocardial Infarction (AMI) is a critical cardiac condition that poses a substantial threat to myocardial function. Expedient diagnosis of AMI is paramount and relies on serological assays for rapid and accurate quantification of relevant biomarkers. Electrochemical sensors have emerged as promising candidates [...] Read more.
Acute Myocardial Infarction (AMI) is a critical cardiac condition that poses a substantial threat to myocardial function. Expedient diagnosis of AMI is paramount and relies on serological assays for rapid and accurate quantification of relevant biomarkers. Electrochemical sensors have emerged as promising candidates for this application, owing to their accessibility, operational simplicity, and high specificity. In this study, we developed a paper-based electrochemical immunosensor to detect cardiac troponin I in serum and saliva specimens. The electrode was fabricated using screen-printing technology with photographic paper as the substrate, employing graphite-based ink, nail polish, and acetone as the solvent. A quasi-reference electrode was constructed using silver powder-based ink, nail polish, and acetone. The immunosensor was prepared by modifying the working electrode with gold nanoparticles (AuNP) functionalized with cardiac troponin I antibodies (anti-cTnI) and bovine serum albumin (BSA). This modified electrode was subsequently used to detect the troponin I antigen. The analyses were performed in 0.1 mol L−1 phosphate buffer medium, pH 7.00, in the presence of 5.0 mmol L−1 of the potassium ferrocyanide probe. The immunosensor exhibited a sensitivity of 0.006 µA/fg mL−1, a limit of detection of 9.83 fg mL−1, and a limit of quantification of 32.79 fg mL−1. Specificity studies conducted in the presence of other macromolecules demonstrated minimal interference, with relative standard deviations (RSD) below 5.00%, indicating a specific interaction with troponin I. Furthermore, the immunosensor demonstrated excellent reproducibility and stability. Upon application to serum and saliva samples, the immunosensor presented recoveries of approximately 99–105%, suggesting its potential applicability in clinical analyses. Full article
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