Special Issue "Combined Catalytic Systems for Organic Synthesis via Cascade and One-Pot Reactions"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: 15 January 2020.

Special Issue Editor

Guest Editor
Prof. Laura Palombi Website E-Mail
Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, 132, 84084-Fisciano, SA, Italy
Interests: stereoselective synthesis; heterocycles; electrosynthesis; electrocatalysis; organocatalysis

Special Issue Information

Dear Colleagues,

The search for new catalytic methods to achieve challenging chemical transformations or improve the efficiency, selectivity, and economy of known protocols plays a pivotal role in organic chemistry, especially for fine chemical and pharmaceutical synthesis. Thanks to the extensive exploiting of cascade, domino, and one-pot catalytic reactions, expeditious and elegant solutions to synthetic problems previously faced with energy-, atom-, and time-consuming procedures and/or waste generation have been proposed. Undoubtedly, in our days, privileged catalysts in this field are organo- and bio-catalysts which effectively conjugate low costs, handiness, and eco-sustainability. On the other hand, these catalysts normally work in homogeneous media, posing a notable problem of separation and recyclability. More recently, the obvious inability of a single catalyst to act as a panacea for all ills inspired researchers to develop ingenious hybrid methods, consisting of the synergistic combination of different techniques or intrinsically distinct catalytic systems, which have been producing amazing advantages over traditional methodologies. As a consequence, items such as “tandem catalytic systems”, “organic–inorganic hybrid catalysts”, “electro-organocatalysis”, “photo-organocatalysts”, and “nano-organocatalysts” have been popping up in literature. Nevertheless, these advances demonstrate there is yet a great deal of scope for further investigations.

This Special Issue intends to collect both research and review articles focused on the most recent achievements and opportunities offered by mixed catalytic systems/techniques in cascade organic reactions and one-pot syntheses in general.

Prof. Laura Palombi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multicatalysts
  • combined catalysis
  • cascade reaction
  • one-pot process

Published Papers (1 paper)

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Research

Open AccessArticle
Developing Multicompartment Biopolymer Hydrogel Beads for Tandem Chemoenzymatic One-Pot Process
Catalysts 2019, 9(6), 547; https://doi.org/10.3390/catal9060547 - 18 Jun 2019
Abstract
Chemoenzymatic processes have been gaining interest to implement sustainable reaction steps or even create new synthetic routes. In this study, we combined Grubbs’ second-generation catalyst with pig liver esterase and conducted a chemoenzymatic one-pot process in a tandem mode. To address sustainability, we [...] Read more.
Chemoenzymatic processes have been gaining interest to implement sustainable reaction steps or even create new synthetic routes. In this study, we combined Grubbs’ second-generation catalyst with pig liver esterase and conducted a chemoenzymatic one-pot process in a tandem mode. To address sustainability, we encapsulated the catalysts in biopolymer hydrogel beads and conducted the reaction cascade in an aqueous medium. Unfortunately, conducting the process in tandem led to increased side product formation. We then created core-shell beads with catalysts located in different compartments, which notably enhanced the selectivity towards the desired product compared to homogeneously distributing both catalysts within the matrix. Finally, we designed a specific large-sized bead with a diameter of 13.5 mm to increase the diffusion route of the Grubbs’ catalyst-containing shell. This design forced the ring-closing metathesis to occur first before the substrate could diffuse into the pig liver esterase-containing core, thus enhancing the selectivity to 75%. This study contributes to addressing reaction-related issues by designing specific immobilisates for chemoenzymatic processes. Full article
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