Biomarkers in the "Omics" Era

A special issue of BioTech (ISSN 2673-6284).

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 22150

Special Issue Editors


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Guest Editor
Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway
Interests: precision medicine; patients stratification; prostate cancer; molecular signatures; androgen receptor; MYC; bromodomain; chromatin; transcriptomics; single cell; gene regulation; radiobiology
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Guest Editor
Division of Medical Oncology, S. Orsola-Malpighi University Hospital, Bologna, Italy
Interests: hepato-biliary-pancreatic cancers; translational medicine; cancer risk factors; cancer biomarkers; cancer genetic; cancer biology; drug discovery; cancer treatment

Special Issue Information

The rapid development of high-throughput technologies has opened up a new “omics” era providing an unprecedented opportunity for scientists and clinicians to gain deeper insights into molecular mechanisms, even at single cell resolution. The analysis and integration of the data arising from these methodological approaches is revolutionizing daily clinical practice, moving the precision medicine paradigm forward. In this scenario, the identification of tissue and circulating molecular biomarkers with high sensitivity and specificity to be employed for diagnosis, prognosis, and treatment prediction will undoubtedly benefit patients, but only few have been successfully implemented into the clinic.

This Special Issue of BioTech includes research articles, short reports, and reviews focused on the employment of “omics” (e.g., genomics, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics, microbiomics) technologies for biomarker development both at translational and clinical level.

Dr. Alfonso Urbanucci
Dr. Simona Tavolari
Guest Editors

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Keywords


  • gene signatures
  • oncology
  • free circulating DNA
  • next-generation sequencing
  • molecular biomarkers

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Published Papers (1 paper)

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Review

17 pages, 3071 KiB  
Review
Applications of CRISPR-Cas9 as an Advanced Genome Editing System in Life Sciences
by Kamand Tavakoli, Alireza Pour-Aboughadareh, Farzad Kianersi, Peter Poczai, Alireza Etminan and Lia Shooshtari
BioTech 2021, 10(3), 14; https://doi.org/10.3390/biotech10030014 - 6 Jul 2021
Cited by 30 | Viewed by 21140
Abstract
Targeted nucleases are powerful genomic tools to precisely change the target genome of living cells, controlling functional genes with high exactness. The clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9) genome editing system has been identified as one of the most [...] Read more.
Targeted nucleases are powerful genomic tools to precisely change the target genome of living cells, controlling functional genes with high exactness. The clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9) genome editing system has been identified as one of the most useful biological tools in genetic engineering that is taken from adaptive immune strategies for bacteria. In recent years, this system has made significant progress and it has been widely used in genome editing to create gene knock-ins, knock-outs, and point mutations. This paper summarizes the application of this system in various biological sciences, including medicine, plant science, and animal breeding. Full article
(This article belongs to the Special Issue Biomarkers in the "Omics" Era)
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