Advances in Microfluidic Biosensing
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 9435
Special Issue Editor
Special Issue Information
Dear Colleagues,
Since their widespread adoption in the mid-1990s, microfluidic technologies have progressed from a specialty topic to one that is nearly ubiquitous within the physical and biological sciences—an increase in usage that has also been witnessed within the biosensing world. The small dimensions of a microchannel provide a number of benefits to a biosensor, including increases in sensitivity, reductions in the sample volume required for analysis, and decreases in the size of the overall biosensor.
The initial combinations of microfluidics with biosensors were relatively simple, for example, a planar microchannel used to deliver a sample to the surface of a biosensor. Later, more advanced systems emerged, which have further pushed the boundaries of optimal biosensing operation: microfluidic mixers have been used to increase mass transport of analyte (and further increase the biosensor’s sensitivity); internal microfluidic valving allows a user to rapidly switch between fluidic samples for analysis; and passive pumping methods (or embedded active pumps) allow for further device miniaturization. Because of the colossal variety in biosensor types or, rather, the large range of transduction methods, biocomponents, and electronic packages that constitute a biosensor, the range and style of these associated microfluidic systems is also very large. Modern microfluidic biosensors now range from those based on the ever-popular PDMS, to paper-based flow devices, and to more exotic materials having more robust (and modifiable) characteristics. There has also been a rapid rise in the use of 3D printing to fabricate microfluidics for biosensing systems, which has tremendous potential for the incorporation of more complex fluidic functionalities. The future of this partnership between microfluidics and biosensors continues to lay the foundation for the next generation of biosensors.
Dr. Nicholas Scott Lynn Jr.
Guest Editor
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