Biomimetic External Prostheses Linked to Implantable Electronics: From Manufacturing and Processing to Overall Characterization, Biological Assessment, and Ethical Challenges

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetic Design, Constructions and Devices".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 1041

Special Issue Editors


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Guest Editor
Department of Mechanical Engineering and Aeronautics, Laboratory of Biomechanics and Biomedical Engineering, University of Patras, 26504 Patras, Greece
Interests: biomaterials processing; assessment and application; biomimetics; biomechanics; interaction of human cells and biomaterials; stem and bone cells cultures; tissue regeneration; artificial organs and implantable devices

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Guest Editor
National Institute for Research and Development in Microtechnologies, 26a Erou Iancu Nicolae Street, 077190 Voluntari, Romania
Interests: implantable electrodes; electronic biomaterials and devices; nanotechnology; biomedical sensors; environmental sensors

Special Issue Information

Dear Colleagues,

This Special Issue focuses on novel medical devices that allow for a connection between an external prosthesis and an implantable device. The fabrication of such a system involves key steps associated with regulations and standards, innovations of multifunctional components, biomimetic design, complex characterization with customized lab devices, powering electronics, enabling implantable devices’ biointegration and overall assessment. The challenges are related to providing an optimum design that will harmonically fit with human patterns and offer the patient both comfort and rehabilitation functions. The purpose is to generate knowledge about the fabrication process, evaluation, and implementation of a medical device made of at least one external and one internal component linked to the body. The topics should be around innovative medical devices, with a focus on external and internal structures involving electronics or internal lab-on-a-chip accessories with applications in the rehabilitation of amputees and paralyzed persons, tissue regeneration, or artificial organ construction. Topics include the following:

  • Standards, regulations, and ethical challenges;
  • Design and manufacturing processes;
  • Mechanical/thermomechanical characterization;
  • Electronic performance assessment;
  • Biologic performance assessment;
  • Processing of components for property improvement and multifunctionality;

Dr. Diana V. Portan
Dr. Carmen Moldovan
Guest Editors

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Keywords

  • implantable devices
  • biomimetic biomaterials
  • biomedical electronics
  • powered exoskeletons

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Published Papers (1 paper)

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Research

15 pages, 5159 KiB  
Article
Cytocompatibility Study of Stainless Steel 316l Against Differentiated SH-SY5Y Cells
by Eleni Zingkou, Asimina Kolianou, Georgios Angelis, Michail Lykouras, Malvina Orkoula, Georgios Pampalakis and Georgia Sotiropoulou
Biomimetics 2025, 10(3), 169; https://doi.org/10.3390/biomimetics10030169 - 11 Mar 2025
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Abstract
Stainless steel (SS) 316l constitutes a popular biomaterial with various applications as implants in cardiovascular and orthopedic surgery, as well as in dentistry. Nevertheless, its cytocompatibility against neuronal cells has not been investigated, a feature that is important for the construction of implants [...] Read more.
Stainless steel (SS) 316l constitutes a popular biomaterial with various applications as implants in cardiovascular and orthopedic surgery, as well as in dentistry. Nevertheless, its cytocompatibility against neuronal cells has not been investigated, a feature that is important for the construction of implants that require contact with neurons, e.g., neuronal electrodes. In addition, most cytocompatibility studies have focused on decorated or surface-modified SS 316l. On the other hand, SH-SY5Y cells are an established cellular model for cytocompatibility studies of potential biomaterials given their ability to differentiate into neuron-like cells. Here, we used retinoic-acid-differentiated SH-SY5Y cells and SH-SY5Y controls to investigate the cytocompatibility and biomimetics of uncoated SS 316l. The assessment of cytocompatibility was based on the determination of differentiation markers by immunofluorescence, RT-qPCR, and the neurite growth of these cells attached on SS 316l and standard tissue culture polystyrene (TCP) surfaces. Even though the neurite length was shorter in differentiated SH-SY5Y cells grown on SS 316l, no other significant changes were found. In conclusion, our results suggest that the uncoated SS 316l mimics a natural bio-surface and allows the adhesion, growth, and differentiation of SH-SY5Y cells. Therefore, this alloy can be directly applied in the emerging field of biomimetics, especially for the development of implants or devices that contact neurons. Full article
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