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Recent Advances in Oral Medicine—2nd Edition
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Recent Advances in Oral Medicine—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 4763

Special Issue Editors

Prof. Dr. Arkadiusz Dziedzic

E-Mail Website
Guest Editor
Department of Conservative Dentistry with Endodontics, Medical University of Silesia, 40-055 Katowice, Poland
Interests: oral medicine; head and neck cancer; oral pathology; oral manifestations of systemic diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Robert Kubina

E-Mail Website
Guest Editor
1. Silesia LabMed: Centre for Research and Implementation, Medical University of Silesia in Katowice, 41-752 Katowice, Poland
2. Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland
Interests: use of natural product in the treatment in neoplastic diseasesmechanism of biological activity of natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to invite you to submit your latest research and insights for consideration to a Special Issue on oral medicine, an interdisciplinary field that focuses on the diagnosis and treatment of oral diseases and conditions that affect the mouth and surrounding structures. This Special Issue aims to provide a platform for the dissemination of high-quality research that advances the understanding and treatment of oral diseases. We welcome submissions from researchers, clinicians, and academics from around the world who are working in areas related to oral medicine, including, but not limited to the following:

  • Oral cancer, benign oral neoplasms, and reactive oral pathologies;
  • Salivary gland disorders;
  • Orofacial pain;
  • Oral mucosa diseases;
  • Periodontal diseases;
  • Hereditary orofacial disturbances.

We also encourage submissions that address broader topics, such as oral health disparities and emerging technologies as well as techniques. We welcome contributions from a broad range of topics related to oral pathology, oral microbiology, oral oncology, oral immunology, and orofacial manifestations of systemic diseases. Authors are encouraged to submit original research and reviews that address important questions in oral medicine.

The global increase in polypharmacy and multidirectional interactions is deemed to induce or aggravate allergic/autoimmune reactions affecting oral health. In addition, novel systemic therapies based on monoclonal antibodies, CAR-T/CRISPR biotechnology, and bisphosphonates can impact the function/integrity of oral tissue. Inevitably, it is predicted that demographic changes and extended lifespans are risk factors for more prevalent oral pathologies in medically compromised individuals afflicted with complex underlying conditions. Lastly, in light of COVD-19 pandemic, some infectious systemic diseases possess a real threat to the oral environment.

Prof. Dr. Arkadiusz Dziedzic
Dr. Robert Kubina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • oral manifestations of systemic conditions
  • drug-induced lesions
  • oral pathologies
  • head and neck cancer
  • autoimmune
  • oral lesions
  • bisphosphonates
  • systemic pharmacotherapy
  • infectious diseases

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (4 papers)

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Research

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15 pages, 946 KB  
Article
Salivary Biomarker Profiles in Pediatric Oral Candidiasis
by Alexandru-Emilian Flondor, Irina-Georgeta Sufaru, Ioana Martu, Stefan-Lucian Burlea and Vasilica Toma
Biomedicines 2025, 13(11), 2837; https://doi.org/10.3390/biomedicines13112837 - 20 Nov 2025
Viewed by 423
Abstract
Background/Objectives: Pediatric periodontal inflammation arises from complex host–microbe interactions. Beyond bacterial biofilms, fungal colonization—particularly by Candida albicans—is increasingly recognized as a contributor. The aim of this study was to investigate the relationship between fungal and bacterial colonization, host inflammatory mediators, and salivary [...] Read more.
Background/Objectives: Pediatric periodontal inflammation arises from complex host–microbe interactions. Beyond bacterial biofilms, fungal colonization—particularly by Candida albicans—is increasingly recognized as a contributor. The aim of this study was to investigate the relationship between fungal and bacterial colonization, host inflammatory mediators, and salivary parameters in children. It also aimed to identify salivary biomarkers that could be useful for the early diagnosis of oral candidiasis and periodontal inflammation. Methods: A cross-sectional study was performed on 140 children (8–15 years): healthy controls (n = 70) and cases with oral candidiasis (n = 70). Clinical indices (Plaque Index, Gingival Index, Bleeding on Probing), salivary flow, pH, and buffering capacity were recorded. Quantitative PCR assessed C. albicans and four periodontal pathogens, while ELISA measured salivary cytokines (IL-1β, IL-6, TNF-α, IL-8). Analyses included group comparisons, correlations, regression modeling, and principal component analysis (PCA). Results: Children with candidiasis exhibited higher PI, GI, and BOP (p < 0.001), along with reduced pH and buffering capacity (p < 0.001). Salivary loads of C. albicans and all targeted pathogens were elevated (p < 0.001). Cytokine levels were markedly increased (p < 0.001). GI correlated with C. albicans (ρ = 0.71) and cytokines (ρ = 0.62–0.76). Logistic regression identified C. albicans and IL-1β as independent predictors, while salivary pH and flow were found to be protective. PCA distinguished groups, with PC1 (55.2%) driven by fungal and cytokine markers. Conclusions: Oral candidiasis in children is defined by distinct microbial and inflammatory profiles. Salivary biomarker integration offers potential for early, non-invasive diagnosis and risk stratification. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine—2nd Edition)
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Review

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25 pages, 2273 KB  
Review
CRISPR Genome Editing in Personalized Therapy for Oral and Maxillofacial Diseases: A Scoping Review
by Arkadiusz Dziedzic, Robert Kubina, Magdalena Skonieczna, Marcel Madej, Jakub Fiegler-Rudol, Mushriq Abid, Doaa Nadhim and Marta Tanasiewicz
Biomedicines 2025, 13(11), 2745; https://doi.org/10.3390/biomedicines13112745 - 10 Nov 2025
Viewed by 1287
Abstract
Background: CRISPR/Cas genome editing is emerging as a powerful tool in oral and maxillofacial medicine, with potential applications in personalized therapies for conditions that currently lack durable treatments. Objectives: This scoping review aimed to map existing evidence on CRISPR-based applications in oral [...] Read more.
Background: CRISPR/Cas genome editing is emerging as a powerful tool in oral and maxillofacial medicine, with potential applications in personalized therapies for conditions that currently lack durable treatments. Objectives: This scoping review aimed to map existing evidence on CRISPR-based applications in oral and maxillofacial fields, rather than to assess treatment effectiveness. Methods: A systematic search of PubMed, Scopus, Web of Science, and ClinicalTrials.gov (2012–2024) identified studies and registered trials involving CRISPR with oral health relevance. Eligible articles included peer-reviewed experimental reports and clinical trials. Results: From 1437 records, 121 studies met inclusion criteria: 106 preclinical reports and 15 clinical or translational studies. Investigated domains included oral cancer therapy, hereditary craniofacial syndromes, regenerative strategies, infectious disease models, and pathogen detection. Early clinical efforts focus mainly on CRISPR-edited T-cell immunotherapies in oncology. Major barriers include off-target effects, delivery challenges, regulatory complexity, and ethical concerns. Conclusions: CRISPR-based bioengineering shows strong promise for precision care in oral and maxillofacial medicine. However, current evidence remains largely preclinical and heterogeneous. No clinical recommendations can yet be made, and translation will depend on rigorous late-phase trials, ethical oversight, and health-economic evaluation. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine—2nd Edition)
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15 pages, 1894 KB  
Review
A Comparative Analysis of Radiological Imaging and Surgical Treatments for Maxillary Artery Pseudoaneurysms, Based on a Literature Review and Our Clinical Experience
by Kinga Samól, Adam Michcik, Barbara Wojciechowska, Adam Polcyn, Łukasz Garbacewicz and Barbara Drogoszewska
Biomedicines 2025, 13(6), 1410; https://doi.org/10.3390/biomedicines13061410 - 9 Jun 2025
Viewed by 869
Abstract
Background/Objectives: A pseudoaneurysm forms as a result of disruption of all artery wall layers. In the head and neck, they are most commonly found in the maxillary artery. Due to their location and associated symptoms, detailed radiological imaging is necessary to determine [...] Read more.
Background/Objectives: A pseudoaneurysm forms as a result of disruption of all artery wall layers. In the head and neck, they are most commonly found in the maxillary artery. Due to their location and associated symptoms, detailed radiological imaging is necessary to determine the nature and extent of lesions. Various treatment methods are available. Methods: To systematize symptoms, diagnostics, and treatment methods, a literature review from databases spanning 2014 to 2024 was conducted, with 30 articles included in the study. Results: The factors that caused MAPs included facial trauma (n = 33; 66%), iatrogenic surgical procedures (n = 14; 28%), head and neck radiotherapy (n = 1; 2%), infection (n = 1; 2%), and one case due to an idiopathic factor (n = 1; 2%). Diagnostic imaging included computed tomography with contrast, magnetic resonance imaging, and angiography. Treatment methods used: endovascular embolization (n = 44; 88%), surgical resection (n = 3; 6%), cauterization (n = 2; 4%), and compression tamponade (n = 1; 2%). Interestingly, three of the cases were treated with endoscopic access (6%). Conclusions: It can be concluded that the most common cause of MAPs is trauma to the facial skeleton, and the most frequently used treatment method is endovascular embolization. Given the need for detailed MAP imaging and treatment in specialized invasive radiology departments, patients with MAPs should be treated in multidisciplinary clinical centers. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine—2nd Edition)
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Other

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16 pages, 1194 KB  
Systematic Review
Artificial Intelligence in the Diagnosis of Tongue Cancer: A Systematic Review with Meta-Analysis
by Seorin Jeong, Hae-In Choi, Keon-Il Yang, Jin Soo Kim, Ji-Won Ryu and Hyun-Jeong Park
Biomedicines 2025, 13(8), 1849; https://doi.org/10.3390/biomedicines13081849 - 30 Jul 2025
Cited by 1 | Viewed by 1683
Abstract
Background: Tongue squamous cell carcinoma (TSCC) is an aggressive oral malignancy characterized by early submucosal invasion and a high risk of cervical lymph node metastasis. Accurate and timely diagnosis is essential, but it remains challenging when relying solely on conventional imaging and [...] Read more.
Background: Tongue squamous cell carcinoma (TSCC) is an aggressive oral malignancy characterized by early submucosal invasion and a high risk of cervical lymph node metastasis. Accurate and timely diagnosis is essential, but it remains challenging when relying solely on conventional imaging and histopathology. This systematic review aimed to evaluate studies applying artificial intelligence (AI) in the diagnostic imaging of TSCC. Methods: This review was conducted under PRISMA 2020 guidelines and included studies from January 2020 to December 2024 that utilized AI in TSCC imaging. A total of 13 studies were included, employing AI models such as Convolutional Neural Networks (CNNs), Support Vector Machines (SVMs), and Random Forest (RF). Imaging modalities analyzed included MRI, CT, PET, ultrasound, histopathological whole-slide images (WSI), and endoscopic photographs. Results: Diagnostic performance was generally high, with area under the curve (AUC) values ranging from 0.717 to 0.991, sensitivity from 63.3% to 100%, and specificity from 70.0% to 96.7%. Several models demonstrated superior performance compared to expert clinicians, particularly in delineating tumor margins and estimating the depth of invasion (DOI). However, only one study conducted external validation, and most exhibited moderate risk of bias in patient selection or index test interpretation. Conclusions: AI-based diagnostic tools hold strong potential for enhancing TSCC detection, but future research must address external validation, standardization, and clinical integration to ensure their reliable and widespread adoption. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine—2nd Edition)
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