Biomarker, Phenotyping and Therapeutics for Asthma

Dear Colleagues,

Asthma is one of the most prevalent chronic airway diseases worldwide, characterised by marked clinical variability and substantial biological heterogeneity. Despite advances in our understanding, the diagnosis of asthma remains challenging, with no single definitive test, contributing to misdiagnosis and inappropriate treatment. Furthermore, although precision medicine has emerged for severe asthma through the introduction of biologic therapies, this applies to only a minority of patients; the majority continue to be managed with one-size-fits-all approaches that overlook the heterogeneity of individual disease endotypes.

This Special Issue seeks to bring together cutting-edge mechanistic and translational research that bridges fundamental biology with clinical application. We welcome studies that (i) identify and validate novel biomarkers for asthma diagnosis, endotyping and disease monitoring; (ii) provide experimental insights into asthma pathophysiology across immune, epithelial and airway mechanical pathways; (iii) apply multi-omics, exhaled breath analysis and advanced physiological measures to refine phenotyping and uncover therapeutic targets; and (iv) explore novel molecular pathways and therapeutic strategies. 

Dr. Ran Wang
Guest Editor

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