Regulatory Role of ECM Biophysical Signals on Cell and Nuclear Mechanics
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3167
Special Issue Editors
Interests: Cell and ECM mechanics; mechanobiology; biomaterials; tissue engineering
Interests: Mechanosensing; Mechanotransduction; Focal Adhesions; Matrix Mechanics; Lab-on-chip devices; Biomaterials; Tissue Engineering; Nanomedicine
Special Issue Information
Dear Colleagues,
In vivo, cells are continuously exposed to multiple microenvironmental stimuli, such as chemical, topographic, and mechanical gradients encased within the extracellular matrix, which control their time and space presentation to tightly regulate cell and tissue functions. Recently, it has been appreciated that extracellular-borne forces are transmitted to the nucleus via the cytoskeletal filaments and biochemical signaling to alter the chromatin organization, inter-chromosome contacts, and gene expression programs. This foundation of mechanobiology aims to link the regulatory role of biophysical signals on cell functions (i.e., migration, differentiation, and neoplastic transformation) with the tensional status of the cytoskeleton along with the mechanical interplay between cytoskeletal forces and nuclear envelope deformation.
Focusing on these key aspects, we believe that this Special Issue offers the opportunity to develop a deeper understanding of the mechanisms that regulate mechanically induced alterations in chromatin organization and their effects on cell state and fate by assessing cell cytoskeleton mechanics in a proper extracellular context. In this Special Issue, we provide researchers working in different but congruent areas of research—such as bioengineering, biomedical engineering, biophysics, material science, and tissue engineering—the opportunity to address these fundamental mechanisms by disclosing the existing relationships between the biophysical properties of cell microenvironments and cell mechanical properties.
Dr. Valeria Panzetta
Dr. Sabato Fusco
Guest Editors
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