Neuropathic Pain: Therapy and Mechanisms 2.0

Dear Colleagues,

Neuropathic pain, known to originate from abnormal or damaged nerves, often manifests as shooting or burning pain, especially burdensome when it turns chronic, negatively impacting the well-being of patients, their social relationships, daily activities, as well as work productivity, the economic burden associated with chronic pain estimated to exceed 500 billion USD per annum, indicating the great impact of this condition. The treatment of chronic neuropathic pain includes physical and psychological therapies, as well as pharmacological, interventional, and surgical treatments, opioids often prescribed to patients who fail to achieve satisfactory pain relief with conventional treatment. However, evidence shows that opioids provide clinically meaningful pain relief in the short-term, whereas their chronic use can result in tolerance as well as dependence. The use of opioids for the management of chronic pain has received significant attention in recent decades, and several additional pharmacological and non-pharmacological treatments have been developed and approved for chronic pain management. This Special Issue on neuropathic pain intends to present the progress in the treatment of chronic pain and highlight the current understanding of pathophysiological and biochemical pathways involved in neuropathic pain, and all article types related to neuropathic pain, pathophysiology, treatment (pharmacological as well as non-pharmacological), and biomarkers will be considered within the scope of this Special Issue.

Dr. Anand Rotte
Guest Editor

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