Molecular Mechanisms and Translational Aspects of Ischemia-Reperfusion Injury

Dear Colleagues,

Ischemia reperfusion injury (IRI) is a relevant pathophysiological mechanism in different fields of vascular surgery (e.g., IRI following acute limb ischemia and IRI of the spinal cord in aortic aneurysm therapy), but also affects other specialties such as solid organ transplantation and cardiothoracic surgery. Besides the clinical consequences of IRI on the outcome of patients, the molecular mechanisms involved in IRI have been the focus of numerous research projects in the past. Defining specific pathways involved in IRI (e.g., reactive oxygen species, free radicals, mitochondrial pathways) is essential to find new therapeutic targets and develop techniques to mitigate or prevent IRI.

In this Special Issue of Biomedicines, we invite you to contribute original research articles, reviews or commentaries on all aspects related to the theme of “Molecular Mechanisms and Translational Aspects of Ischemia-Reperfusion Injury”.

The aim of this Special Issue of Biomedicines is to cover and discuss all experimental, translational as well as clinical aspects of molecular mechanisms involved in the pathophysiology of IRI at biochemical, cellular, functional and translational levels.

Dr. Alexandra Gratl
Prof. Dr. Sabine Helena Wipper
Dr. Florian Enzmann
Guest Editors

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