Adiposity and Adipokines: Roles in the Local Spread of Cancer and in the Metastasis Development
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 2963
Special Issue Editor
Interests: breast cancer; bone metastasis; tumor microenvironment; invasive growth; epithelial–mesenchymal transition; autophagy; signal transduction; immunohistochemistry; animal models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A highly heterogeneous population of cells in the microenvironment surrounding tumor cells is responsible for a large number of factors that are important for cancer spread and metastasis, highlighting the importance of tumor–microenvironment cross-talk in influencing tumor growth progression. In this context, adipocytes assume a relevant role: They are capable of producing different factors (i.e., adipokines, cytokines, and chemokines); among them, leptin, adiponectin, resistin, autotaxin, and IL-6 are relevant signals arising from tumor stroma, involved in the initiation and progression of cancer. Moreover, many adipokines, through up- or down-regulation of miRNAs, exert oncogenic or anti-tumor effects. In particular, bone marrow adipose tissue (BMAT) is beginning to emerge as an important contributor to cancer progression in bone metastasis. In addition to producing a plethora of adipokines, BMAT releases extracellular vesicles, which may influence cells in the surrounding area. However, the role of adipocytes and adipose tissue in the metastatic microenvironment remains an important issue to be explored: More detailed knowledge of the link(s) between adiposity and cancer development is needed to find new targets to counteract cancer local invasion and metastasis.
This Special Issue aims to collect recent results regarding the link between adiposity and cancer development and spread to local and distant sites, and to focus on the potential of adipokines and their signaling axes as targets in cancer therapy. Original articles and reviews will be considered.
This Special Issue is jointly organized between IJMS and Biomedicines. In accordance with the Aims and Scope of these journals, articles showing basic studies in biochemistry, molecular biology, and molecular medicine can be submitted to IJMS, whereas articles presenting more clinical content can be submitted to Biomedicines.
Dr. Paola Maroni
Guest Editor
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Keywords
- cancer
- metastasis
- tumor microenvironment
- adipocytes
- adiposity
- adipokines
- obesity
- bone marrow adipose tissue
- miRNAs
- extracellular vesicles
- therapy
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