The Role of Adenosine A(2A) Receptor Antagonists in Neurology and Psychiatric Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2895
Special Issue Editors
Interests: neurodegenerative disease; Parkinson's disease (PD)
Special Issue Information
Dear Colleagues,
The identification and cloning of the adenosine A2A receptor and the finding of its selective localisation to the brain—most notably to neurones in the basal ganglia and in limbic brain regions—and to glial cells, opened a new vista on approaches to the treatment of both neurological and psychiatric illnesses and to the potential for achieving neuroprotection and/or disease modification. In this supplement, we explore the molecular biology, biochemistry and functional roles of the adenosine A2A receptor. These are put into the context of the use of adenosine A2A receptor antagonists in the symptomatic treatment of Parkinson’s disease and the acceptable safety profile in combination with current dopaminergic therapies. In addition, we look at the functional significance of the adenosine A2A receptor in a range of other neurodegenerative diseases, including motor neurone disease, Huntington’s chorea and multiple sclerosis. We also explore the potential of adenosine A2A receptors and A2A receptor antagonists as a novel approach for the treatment of anxiety, depression, cognition and sleep disturbance. Finally, the key localisation of A2A receptors on glutamatergic neurones and their role in the control of excitotoxic mechanisms together with their involvement in the regulation of glial cell activity are used to illustrate how adenosine A2A receptor antagonists may have a future role in modifying the progression of degenerative illnesses of the central nervous system.
Dr. Peter Jenner
Dr. Akihisa Mori
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- adenosine
- adenosine A2A receptor
- adenosine A2A receptor antagonist
- basal ganglia
- limbic system Parkinson’s disease
- neurodegeneration
- motor neuron disease
- Huntington's disease
- anxiety
- depression
- cognition
- sleep disturbance. glutamatergic neurons
- glial cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.