Engineering of Functional Micro-/Nanoparticles for Stem Cell Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3675

Special Issue Editor

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Interests: design of drug delivery systems using microfluidics platforms; high-throughput screening platform for nanomaterials; engineering of micro/nano particles for stem cell therapy

Special Issue Information

Dear Colleagues,

A large number of clinical trials have demonstrated the effectiveness of stem cell therapy as an alternative therapeutic paradigm over the conventional approaches for autoimmune, inflammatory, neurological, and orthopedic diseases, as well as traumatic injuries. For an ideal therapeutic effect, a sufficient number of stem cells must be retained at the injury site or migrate to the targeted tissues to exert long-term biological effects. In addition, the successful implementation of stem cell therapy requires a comprehensive understanding of cell fate after transplantation, including cell localization, survival, and differentiation. Despite the obvious merits of stem cell therapy, so far, it is difficult to realize the aforementioned functional therapeutic benefits by using stem cells alone.

Recent research has demonstrated the distinct effects of functional micro-/nanoparticles, including their propensity for controlled drug release, cell retention and engraftment at the injury site, cell fate modulation, biomedical imaging, and so on, thereby paving the way for stem cell engineering as an effective disease treatment. This Special Issue aims to include research on the design, fabrication, and multiple biomedical applications of functional micro-/nanoparticles for enhancing stem cell therapy. The types of functional micro-/nanoparticles include drug-delivery systems, hydrogel microspheres, labeling agents, artificial exoskeletons, etc. All relevant basic and clinical results will be considered for publication in this Special Issue.

Dr. Ming Ma
Guest Editor

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Keywords

  • stem cell therapy
  • micro-/nanoparticles
  • drug delivery
  • regenerative medicine

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Published Papers (1 paper)

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Review

24 pages, 2966 KiB  
Review
Insight on Oxygen-Supplying Biomaterials Used to Enhance Cell Survival, Retention, and Engraftment for Tissue Repair
by Muhammad Rafique, Onaza Ali, Muhammad Shafiq, Minghua Yao, Kai Wang, Hiroyuki Ijima, Deling Kong and Masato Ikeda
Biomedicines 2023, 11(6), 1592; https://doi.org/10.3390/biomedicines11061592 - 30 May 2023
Cited by 11 | Viewed by 3161
Abstract
Oxygen is one of the essential requirements for cell survival, retention, and proliferation. The field of regenerative medicine and tissue engineering (TE) has realized considerable achievements for the regeneration of tissues. However, tissue regeneration still lacks the full functionality of solid organ implantations; [...] Read more.
Oxygen is one of the essential requirements for cell survival, retention, and proliferation. The field of regenerative medicine and tissue engineering (TE) has realized considerable achievements for the regeneration of tissues. However, tissue regeneration still lacks the full functionality of solid organ implantations; limited cell survival and retention due to oxidative stress and hypoxia in the deeper parts of tissues remains a perpetual challenge. Especially prior to neovascularization, hypoxia is a major limiting factor, since oxygen delivery becomes crucial for cell survival throughout the tissue-engineered construct. Oxygen diffusion is generally limited in the range 100–200 μm of the thickness of a scaffold, and the cells located beyond this distance face oxygen deprivation, which ultimately leads to hypoxia. Furthermore, before achieving functional anastomosis, implanted tissues will be depleted of oxygen, resulting in hypoxia (<5% dissolved oxygen) followed by anoxic (<0.5% dissolved oxygen) microenvironments. Different types of approaches have been adopted to establish a sustained oxygen supply both in vitro and in vivo. In this review, we have summarized the recent developments in oxygen-generating and/or releasing biomaterials for enhancing cell survival in vitro, as well as for promoting soft and hard tissue repair, including skin, heart, nerve, pancreas, muscle, and bone tissues in vivo. In addition, redox-scavenging biomaterials and oxygenated scaffolds have also been highlighted. The surveyed results have shown significant promise in oxygen-producing biomaterials and oxygen carriers for enhancing cell functionality for regenerative medicine and TE applications. Taken together, this review provides a detailed overview of newer approaches and technologies for oxygen production, as well as their applications for bio-related disciplines. Full article
(This article belongs to the Special Issue Engineering of Functional Micro-/Nanoparticles for Stem Cell Therapy)
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