Current Aspects on the Therapeutics of Aging, Cellular Senescence and Neurodegenerative Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 351

Special Issue Editor

Special Issue Information

Dear Colleagues,

Aging is an inevitable  process causing deteriorations in brain function. The aging process is described by the buildup of senescent cells and a decline in the ability to maintain essential homeostatic functions. An accumulation of damaged proteins, inflammation and cell death have all been linked to cellular aging, which has been linked with the development of neurodegenerative disorders. Alzheimer’s disease (AD) is an age-associated neurodegenerative disease (ND) which impairs memory and cognition, and affects behavioral and social activities. AD is the most common brain disease in the world, affecting 4–8% of the elderly population worldwide. Prevalence studies indicate that the global AD population will proliferate to 114 million by 2050. Increasing evidence has proved that autophagy–lysosomal pathway deficiency plays key roles in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD) manifested by memory loss. At present, exploring cellular senescence as a potential therapeutic target for addressing neurodegenerative diseases has increasingly received the attention of researchers. Despite a plethora of laboratory as well as clinical research, there is a dearth of effective medicine. Therefore, it poses great challenges for researchers in the scientific community and medical experts to tackle the unresolved problems of disease pathogenesis and therapeutics for aging, cellular senescence and neurodegenerative diseases. Among the most promising strategies for drug discovery is employing traditional herbal medicine for the modulation of memory improvement and toxic protein degradation in aging, cellular senescence and neurodegenerative diseases therapy.

Dr. Ashok Iyaswamy
Guest Editor

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Keywords

  • therapeutics
  • neurodegenerative diseases
  • aging
  • cellular senescence
  • Alzheimer’s disease
  • Parkinson’s disease

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Published Papers (1 paper)

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Review

24 pages, 1306 KiB  
Review
Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging Therapies
by Raluca Jipu, Ionela Lacramioara Serban, Ancuta Goriuc, Alexandru Gabriel Jipu, Ionut Luchian, Carmen Amititeloaie, Claudia Cristina Tarniceriu, Ion Hurjui, Oana Maria Butnaru and Loredana Liliana Hurjui
Biomedicines 2025, 13(8), 1927; https://doi.org/10.3390/biomedicines13081927 - 7 Aug 2025
Abstract
Dermal fibroblasts, the primary stromal cells of the dermis, exhibit remarkable plasticity in response to various stimuli, playing crucial roles in tissue homeostasis, wound healing, and ECM production. This study examines the molecular mechanisms underlying fibroblast plasticity, including key signaling pathways, epigenetic regulation, [...] Read more.
Dermal fibroblasts, the primary stromal cells of the dermis, exhibit remarkable plasticity in response to various stimuli, playing crucial roles in tissue homeostasis, wound healing, and ECM production. This study examines the molecular mechanisms underlying fibroblast plasticity, including key signaling pathways, epigenetic regulation, and microRNA-mediated control. The impact of aging on ECM synthesis and remodeling is discussed, and the diminished production of vital components such as collagen, elastin, and glycosaminoglycans are highlighted, alongside enhanced ECM degradation through upregulated matrix metalloproteinase activity and accumulation of advanced glycation end products. The process of cellular senescence in dermal fibroblasts is explored, with its role in skin aging and its effects on tissue homeostasis and repair capacity being highlighted. The senescence-associated secretory phenotype (SASP) is examined for its contribution to chronic inflammation and ECM disruption. This review also presents therapeutic perspectives, focusing on senolytics and geroprotectors as promising strategies to combat the negative effects of fibroblast senescence. Current challenges in translating preclinical findings to human therapies are addressed, along with future directions for research in this field. This comprehensive review explores the complex interplay between dermal fibroblast plasticity, cellular senescence, and extracellular matrix (ECM) remodeling in the context of skin aging. In conclusion, understanding the complex interplay between dermal fibroblast plasticity, cellular senescence, and extracellular matrix (ECM) remodeling is essential for developing effective anti-aging interventions, which highlights the need for further research into senolytic and geroprotective therapies to enhance skin health and longevity. This approach has shown promising results in preclinical studies, demonstrating improved skin elasticity and reduced signs of aging. Full article
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