Mechanistic Insights of Selective Autophagy in Neurodegenerative Diseases

Dear Colleagues,

Selectively targeting cytosolic components or organelles for degradation is a major surveillance mechanism employed in several cell types and animal models. Damaged organelles and protein aggregates are crucial hallmarks of several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and so on. In this process, several selective autophagy receptors bind to the dysregulated cellular cargo via the Atg8/LC3/GABARAP proteins and promote their degradation. Modulating quality control mechanisms can alleviate the devastating effects of neurodegenerative diseases.

This Special Issue will focus on recent advances in selective autophagy in neurodegenerative diseases, aiming to foster an improved understanding of the roles of selective autophagy in the pathogenesis, propagation, and therapeutics of various neurodegenerative diseases.

We are inviting the submission of original research articles and reviews on, but not limited to: new findings on molecular key players, biomarkers, risk factors, molecular mechanisms, and therapeutic targets of neurodegenerative diseases.

Dr. Ashok Iyaswamy
Dr. Chun Kit Benjamin Tong
Dr. Sreenivasmurthy Sravan Gopalkrishnashetty
Guest Editors

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