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Biomedicines
Special Issues
Kidney Disease: From Pathophysiology to Treatment
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Kidney Disease: From Pathophysiology to Treatment

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: 28 February 2026 | Viewed by 219

Special Issue Editors

Dr. Paola Pontrelli

E-Mail Website
Guest Editor
Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Piazza Giulio Cesare n. 11, 70124 Bari, Italy
Interests: genomics; transcriptomics; diabetic nephropathy; kidney transplantation
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Conserva

E-Mail Website
Guest Editor
Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Piazza Giulio Cesare n. 11, 70124 Bari, Italy
Interests: kidney; biomarker; nephropathy; diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Kidney disease represents a major global health burden, encompassing a wide spectrum of acute and chronic conditions that significantly impact morbidity, mortality, and healthcare systems. Despite advances in clinical management, the underlying mechanisms driving disease onset and progression include complex and multifactorial mechanisms that are not yet fully elucidated. Progress in molecular biology, genetics, immunology, and systems medicine has provided new insights into the processes of inflammation, fibrosis, oxidative stress, and maladaptive repair that drive renal injury and progression. Nevertheless, current therapeutic strategies remain largely supportive, and disease-modifying treatments are limited.

This Special Issue “Kidney Disease: From Pathophysiology to Treatment” invites original research articles and reviews that address the multifaceted nature of kidney disease. We welcome original research and reviews addressing cellular and molecular mechanisms of kidney injury, biomarker discovery and validation, genetic and epigenetic determinants, innovative pharmacological interventions, regenerative strategies, and precision medicine approaches.

By integrating contributions across basic and translational research, this Special Issue seeks to promote an integrated understanding of kidney disease and stimulate the development of effective strategies to prevent, diagnose, and to inform the development of effective interventions that can improve patient outcomes.

Dr. Paola Pontrelli
Dr. Francesca Conserva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute kidney injury
  • chronic kidney disease
  • precision medicine
  • molecular mechanisms
  • biomarkers
  • therapeutic response

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Published Papers (1 paper)

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16 pages, 1084 KB  
Review
State-of-the-Art Research and New Pharmacological Perspectives on Renal Involvement in Duchenne Muscular Dystrophy: A Narrative Review
by Michela De Bellis, Paola Imbrici, Roberta Lenti, Antonella Liantonio and Annamaria De Luca
Biomedicines 2026, 14(1), 230; https://doi.org/10.3390/biomedicines14010230 - 21 Jan 2026
Abstract
Background: Although Duchenne muscular dystrophy (DMD) is primarily characterized as a skeletal muscle-wasting disorder, the resulting pathophysiological changes extend to multiple non-muscle tissues and organ systems. Among these, renal and urinary tract dysfunctions have been reported, albeit in relatively few studies, as [...] Read more.
Background: Although Duchenne muscular dystrophy (DMD) is primarily characterized as a skeletal muscle-wasting disorder, the resulting pathophysiological changes extend to multiple non-muscle tissues and organ systems. Among these, renal and urinary tract dysfunctions have been reported, albeit in relatively few studies, as potential complications in DMD patients, sometimes occurring from an early age. Importantly, as life expectancy improves, the incidence of renal impairment is also expected to increase. This narrative review summarizes the available evidence on kidney involvement in DMD and discusses the associated biomarkers of renal dysfunction within the context of multisystem disease progression. Methods: The review draws on data from both human and animal studies and analyzes published evidence to explore kidney involvement in DMD, with a focus on clinical manifestations, biomarkers of renal dysfunction, and potential pathogenic mechanisms. Results: Available data indicate a close association between cardiac and renal dysfunction, particularly in patients with advanced-stage DMD. The review explores potential underlying mechanisms of renal impairment, including intrinsic dystrophin deficiency in the kidney, secondary effects of cardiovascular complications, and the nephrotoxic impact of drug therapies, highlighting renal function as an active determinant of clinical risk. Conclusions: While cardiac function monitoring is already a cornerstone of multidisciplinary care for this multisystem disease, systematic assessment of renal function should also be implemented, with implications for clinical management and drug safety. Moreover, the risk of drug-induced nephrotoxicity warrants attention in both clinical management and the development of novel therapeutic strategies for DMD. Full article
(This article belongs to the Special Issue Kidney Disease: From Pathophysiology to Treatment)
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