New Advances in Sjögren's Syndrome: Towards Novel Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 325
Special Issue Editor
Special Issue Information
Dear Colleagues,
Among autoimmune diseases, Sjogren’s syndrome (SS) is one of the most common. The major characteristics of the disease are exocrine gland inflammation and destruction. Key to understanding the pathophysiology of SS is the observation that the main histological hallmark is mononuclear cell infiltration of the lacrimal and salivary glands. Although new biological regimes have been introduced for many autoimmune diseases, the progress in understanding Sjogren’s pathophysiology remains poor. As such, today we still lack efficient therapy for this disease and so far, early-phase clinical trials have shown controversial results. To this end, it is fundamentally important to revisit and enrich what is known and/or identify novel targetable mechanisms, factors and signals that initiate the abnormal immune responses, resulting in a break of immune tolerance in SS. This Special Issue invites original research and reviews articles describing the most recent advances in the field of SS, possibly suggesting novel targetable molecules, pathways or mechanisms.
Dr. Stergios Katsiougiannis
Guest Editor
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Keywords
- Sjogren’s syndrome
- autoimmunity
- salivary glands
- epithelial cells
- epithelitis
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