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Biomedicines
Special Issues
Serotonin and Receptors in Disease and Health
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Serotonin and Receptors in Disease and Health

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3845

Special Issue Editor

Dr. Stephanie Watts

E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Interests: vascular smooth muscle pharmacology; physiology and function; 5-HT receptors; health disease; animal models

Special Issue Information

Dear Colleagues,

Serotonin (5-hydroxytryptamine, 5-HT) has come a long way since its discovery in the 1940s, isolated from the blood as a vasoactive substance. We invite you to share your work on 5-HT and its receptors, now 13 subtype members strong, in any area of research (cardiovascular, neuroscience, immune, etc.), as well as share information about tools that could support our 5-HT community.

With this Special Issue of Biomedicines, we focus on the current understanding and future research directions regarding the role of 5-HT and its receptors as key players in disease. We warmly welcome original research and review articles relating to this hot topic. 

Dr. Stephanie Watts
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 5-HT receptors
  • health disease
  • animal models
  • pharmacology
  • physiology

Published Papers (2 papers)

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Research

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7 pages, 886 KiB  
Communication
Skin Vascular Resistance Decreases during 5-HT-Induced Hypotension in the Rat
by Benjamin Butler, Hannah Garver, Stephanie W. Watts and Gregory D. Fink
Biomedicines 2023, 11(2), 547; https://doi.org/10.3390/biomedicines11020547 - 13 Feb 2023
Cited by 1 | Viewed by 1106
Abstract
A recognized vasodilator, the infusion of 5-hydroxytryptamine (5-HT, serotonin) decreases blood pressure through the reduction of total peripheral resistance in the rat. It is not clear which vascular beds/tissues are responsible for this fall. We hypothesized that an increase in blood flow within [...] Read more.
A recognized vasodilator, the infusion of 5-hydroxytryptamine (5-HT, serotonin) decreases blood pressure through the reduction of total peripheral resistance in the rat. It is not clear which vascular beds/tissues are responsible for this fall. We hypothesized that an increase in blood flow within the skin, measured as an elevated temperature (T) in the thermoregulatory tail and paws, enables at least part of 5-HT-induced reduction in blood pressure through active vasodilation. The temperature of thermoregulatory regions of the skin of an anesthetized male, Sprague Dawley rats were measured using a Optris PI640 thermal camera. The blood pressure of the animal and the temperature of each paw and four locations along the tail (TL1-4) were recorded before, during, and after the infusion of 5-HT at a rate of 25 mg/min into a femoral vein. Contrary to our hypothesis, the temperature of the paws and tail was stable before and during 5-HT infusion and actually increased during the 15-min recovery period. This finding suggests that hyperemia of the skin circulation is not necessary for the fall in blood pressure observed with infused 5-HT, but that a reduction in cutaneous vascular resistance plays a part in the fall in total peripheral resistance. Full article
(This article belongs to the Special Issue Serotonin and Receptors in Disease and Health)
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Review

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18 pages, 13113 KiB  
Review
Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
by Abimael González-Hernández, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink and Carlos M. Villalón
Biomedicines 2023, 11(7), 1864; https://doi.org/10.3390/biomedicines11071864 - 29 Jun 2023
Cited by 2 | Viewed by 2379
Abstract
5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated. Briefly, 5-HT can activate: (i) metabotropic (G-protein-coupled) receptors [...] Read more.
5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated. Briefly, 5-HT can activate: (i) metabotropic (G-protein-coupled) receptors to promote inhibition (5-HT1, 5-HT5) or activation (5-HT4, 5-HT6, 5-HT7) of adenylate cyclase, as well as activation (5-HT2) of phospholipase C; and (ii) ionotropic receptor (5-HT3), a ligand-gated Na+/K+ channel. Regarding blood pressure regulation (and beyond the intricacy of central 5-HT effects), this monoamine also exerts direct postjunctional (on vascular smooth muscle and endothelium) or indirect prejunctional (on autonomic and sensory perivascular nerves) effects. At the prejunctional level, 5-HT can facilitate or preclude the release of autonomic (e.g., noradrenaline and acetylcholine) or sensory (e.g., calcitonin gene-related peptide) neurotransmitters facilitating hypertensive or hypotensive effects. Hence, we cannot formulate a specific impact of 5-HT on blood pressure level, since an increase or decrease in neurotransmitter release would be favoured, depending on the type of prejunctional receptor involved. This review summarizes and discusses the current knowledge on the prejunctional mechanisms involved in blood pressure regulation by 5-HT and its impact on some vascular-related diseases. Full article
(This article belongs to the Special Issue Serotonin and Receptors in Disease and Health)
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