Osteosarcoma: From Pathophysiology to Novel Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2633
Special Issue Editor
Interests: osteosarcoma; translational research; bone sarcomas; immunotherapy; cancer metabolism; gastrointestinal cancers; rare tumors
Special Issue Information
Dear Colleagues,
Osteosarcoma (OS) is the most common primitive bone tumor in children and adolescents, with a second peak incidence in older adulthood.
Although treatment with surgery and multiagent intensive chemotherapy results in a 60-70% rate of long-term disease-free survival for localized patients, the chance of curing the disease dramatically drops for metastatic patients and patients with chemoresistant tumors.
The identification of novel therapeutic approaches is challenging due to the rarity of the disease and osteosarcoma’s biological features, such as tumor heterogeneity, complex karyotypes, and genomic instability.
This Special Issue will present a collection of original research articles and reviews highlighting osteosarcoma’s pathophysiologic mechanisms, including epigenetic and metabolic regulation, angiogenesis, microenvironment, and immune system interactions, and will help to address advances in new therapeutic strategies.
Dr. Elisabetta Setola
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- osteosarcoma
- microenvironment
- target therapy
- metabolism
- angiogenesis
- chemotherapy
- therapy resistance
- preclinical models
- cancerogenesis
- immunotherapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.