Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 543

Special Issue Editors


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Guest Editor
Department of Medicine, Cardiology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil
Interests: heart failure; photobiomodulation; stem cells

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Guest Editor
Department of Medicine, Cardiology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil
Interests: heart failure

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Guest Editor
Department of Medicine, Universidade Federal de São Paulo, Sao Paulo, Brazil
Interests: heart failure; photobiomodulation

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Guest Editor
College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA
Interests: arrhythmia; cardiovascular diseases; hemodynamics; nutritional supplements for cardiac diseases

Special Issue Information

Dear Colleagues,

Heart failure (HF) is one of the major challenges in cardiovascular disease, characterized by high morbidity and mortality, with a significant impact on public health expenditure. Current guidelines recommend different classes of drugs, invasive procedures, implantable devices, and lifestyle changes to prevent the progression of HF. Despite advances in recent decades, effective therapeutic interventions remain limited. As a result, progressive cardiac dysfunction, reduced functional capacity, and increased mortality remain commonplace. New, evidence-based therapies are therefore essential. These new approaches will pave the way for promising agents to alter the natural history of HF in the future.

This Special Issue aims to contribute to the knowledge of the pathophysiology of HF and cardiomyopathy. We invite authors to submit experimental/laboratory studies investigating new therapies that may prevent or slow the progression of HF, including innovative pharmacologic and gene and cell therapies.

Prof. Dr. Andrey Jorge Serra
Dr. Ednei Luiz Antonio
Dr. Gianna Móes de Albuquerque-Pontes
Dr. Luis Felipe Neves dos Santos
Guest Editors

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Keywords

  • cardiomyopathy
  • cardiac remodeling
  • heart disease
  • heart failure
  • mechanisms
  • new therapies
  • targeted therapies

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Published Papers (1 paper)

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Research

7 pages, 730 KiB  
Communication
Histological Evaluation for Collagen Expression Prior to LVAD Implantation Is Useful to Estimate Weaning Success
by Maja-Theresa Dieterlen, Lea Schreiber, Kristin Klaeske, Joanna Jozwiak-Nozdrzykowska, Michael A. Borger, Alexey Dashkevich, Sandra Eifert and Michal Nozdrzykowski
Biomedicines 2025, 13(7), 1515; https://doi.org/10.3390/biomedicines13071515 - 20 Jun 2025
Viewed by 357
Abstract
Introduction: The implantation of a left ventricular assist device (LVAD) is a life-saving therapeutic option for patients with advanced heart failure. The treatment goal has to be determined prior to LVAD implantation. However, prognostic evaluation for defining the treatment goal could be improved [...] Read more.
Introduction: The implantation of a left ventricular assist device (LVAD) is a life-saving therapeutic option for patients with advanced heart failure. The treatment goal has to be determined prior to LVAD implantation. However, prognostic evaluation for defining the treatment goal could be improved for a time- and cost-effective medical treatment. Methods: Our study comprised seven patients who were weaned from LVAD (recovery group) and a control group without weaning (non-recovery group; n = 7). Myocardial tissue was analysed for connective tissue content by Masson–Goldner trichrome staining and for collagen I and collagen III expression by quantitative real-time PCR and immunohistochemistry. Results: The histological evaluation revealed comparable values for the percentage of total connective tissue (non-recovery: 46.3% [95% CI: 15.9–76.7], recovery: 43.4% [95% CI: 13.7–73.2], p = 0.43). mRNA expression analysis for collagen I and III expression could not detect a difference in collagen I (p = 0.16) and collagen III expression (p = 0.12) between the non-recovery and the recovery group. Immunohistochemical staining revealed that the percentages of collagen I (p = 0.05) and of collagen III (p = 0.01) were reduced in patients who do not recover compared to patients who recover under LVAD support. Conclusions: Our data indicate that histological evaluation for collagen expression prior to LVAD implantation could detect differences in the collagen content that could be helpful for estimating the weaning success. Full article
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