New Advances in Neurodevelopmental Disorders: From Genetics to Mechanisms

Dear Colleagues,

Neurodevelopmental disorders (NDDs) have proven to be genetically and phenotypically heterogeneous. Many groups have published novel NDD candidate genes from large cohorts, but the lack of understanding of the pathomechanisms for these genetic variants has created a clinical bottleneck. Currently, we have a significantly stronger understanding of the genetics of NDDs compared with molecular mechanisms. Furthermore, we need further information on the clinical phenotypes of individuals with these novel genetic variants to better characterize individual NDDs. With a better understanding of both the molecular mechanisms and phenotypic spectra, targeted therapeutics may become more available. Addressing the gaps between genomics and the clinic is critical for patient care.

This Special Issue of Biomedicines will focus on the data necessary for understanding the full picture of NDDs. This includes primary research and/or review articles focused on molecular or animal studies modeling specific disorders, deep genotype-phenotype analyses, and novel ways to understand the genetics of NDDs.

Dr. Madelyn A. Gillentine
Dr. Jennifer M. Bain
Guest Editors

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