Biliary Tract Cancer: From Molecular Mechanism to Therapeutic Perspectives

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 865

Special Issue Editor


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Guest Editor
Duke-NUS Medical School, Singapore
Interests: molecular mechanisms elucidation and discovery of new therapeutic strategies for cancers

Special Issue Information

Dear Colleagues,

The incidence of biliary tract cancers has been rapidly increasing in recent years. Despite the emergence of FDA-approved drugs for these cancers, mortality rates remain high, and challenges with drug inefficacy and resistance persist. Biliary tract cancers are heterogeneous in nature, with diverse etiologies compounding the challenge of developing effective drug therapies. Elucidating the molecular mechanisms underlying the progression and development of biliary tract cancers is crucial for identifying new targetable vulnerabilities. This research promises to accelerate the drug discovery process for novel therapeutic strategies, though much work remains to be conducted. This Special Issue invites original basic science and translational work in the field to highlight recent scientific findings that could potentially impact patient care.

Dr. Jing Han Hong
Guest Editor

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Keywords

  • biliary tract cancers
  • molecular mechanisms
  • drug discovery
  • therapeutic vulnerabilities
  • translational science

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Published Papers (1 paper)

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Review

21 pages, 1822 KB  
Review
The Role and Function of Non-Coding RNAs in Cholangiocarcinoma Invasiveness
by Yu Meng, Fang Wei, Ye Zhang, Wenting He, Haijiao Yan and Jun Wu
Biomedicines 2025, 13(6), 1369; https://doi.org/10.3390/biomedicines13061369 - 3 Jun 2025
Viewed by 542
Abstract
Cholangiocarcinoma (CCA) is an aggressive tumor that originates from the epithelial cells of the bile duct and has the ability to metastasize to the liver or lymph nodes at an early stage. CCA metastasis represents a complex, multi-stage cascade process. Among these stages, [...] Read more.
Cholangiocarcinoma (CCA) is an aggressive tumor that originates from the epithelial cells of the bile duct and has the ability to metastasize to the liver or lymph nodes at an early stage. CCA metastasis represents a complex, multi-stage cascade process. Among these stages, the acquisition of invasiveness by CCA cells is a critical prerequisite for metastatic progression. Elucidating the molecular mechanisms driving CCA cell invasiveness is critical for advancing our knowledge in this field. Emerging evidence highlights the critical role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). These molecules orchestrate key processes such as the epithelial–mesenchymal transition (EMT), as well as the migration and invasion of CCA cells. Collectively, these processes ultimately drive tumor progression. This review comprehensively synthesizes the expression, biogenesis, interactions, signaling pathways, and functional mechanisms of ncRNAs in the invasiveness of CCA. Furthermore, the review discusses potential clinical applications of ncRNAs, including their roles as diagnostic tools, therapeutic targets, and prognostic markers. These investigations offer novel insights and evidence for identifying early metastasis in CCA, developing specific therapeutic strategies, and enhancing drug resistance. Full article
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