Immunometabolism and Immunity

Dear Colleagues,

Research in immunometabolism is attracting growing interest. Immunometabolism is a cornerstone in adaptative and innate immune regulation, which plays a main role in immune cell reprogramming. Immunometabolism studies have revealed that some metabolites can act as immunomodulators, affecting the six main routes (glycolysis, tricarboxylic acid (TCA) cycle, pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis, and metabolic amino acids) involved in immune cells reprogramming. Some metabolites participate in diverse biological processes, including modulation of vascular resistance, cell growth, survival, and stress, cell membrane structure, and immune responses. As a consequence, they have a powerful impact on health. Immune cell reprogramming is essential to maintain the pro-inflammatory/anti-inflammatory balance and, therefore, homeostasis, according to an organism’s requirements. Immune cell metabolism is remarkably plastic. The loss of this plastic behavior is reflected in specific chronic diseases. Immunostimulation and nutritional approaches could represent an alternative way to ensure optimal health; therefore, the modulation of the level and composition of metabolites could impact the immune system. The main goal of this Special Issue is to present immunometabolism and therapeutic immunometabolites as strategies to approach the treatment of diseases such as cancer, autoimmune disorders, and metabolic dysfunctions.

Dr. Marta Sendra
Dr. Marta Librán
Guest Editors

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• immunometabolism
• immunometabolites
• immune cell reprogramming
• inflammation
• metabolic diseases