Immunology of Hearing

Dear Colleagues,

This Special Issue entitled “Immunology of Hearing“ will gather publications that focus on middle- and inner-ear inflammation and autoimmune pathology, which strongly contribute to hearing loss.

Autoimmune inner ear disease (AIED) is a rare disease that occurs when the body's immune system mistakenly attacks the inner ear, ringing in your ears, and hearing loss. AIEDs include Cogan’s syndrome, relapsing polychondritis, polyarteritis nodosa, granulomatosis with polyangiitis (GPA, previously known as Wegener’s granulomatosis), ulcerative colitis, Sjogren’s syndrome, and rheumatoid arthritis. The mechanisms of AIEDs are still unknown.

Otitis media (OM) is a middle ear disease and public health problem with over 5 billion dollars spent every year globally on this disease (https://doi.org/10.1371/journal.pone.0036226).

The auditory ossicles in the middle ear consist of bone. Pathology of acute OM and chronic suppurative OM (CSOM) are characterized by infection, immunological pathology, and cytokines. Bone resorption including osteoclasts and osteoblasts should also be discussed because auditory ossicles are resorbed by cytokines.

Dr. Sho Kanzaki
Guest Editor

Manuscript Submission Information

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• immunology
• inner ear
• middle ear
• autoimmune hearing loss
• bone resorption
• otitis media