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Biomedicines
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Biomaterials and Nanotechnology for Advanced Wound Dressings
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Biomaterials and Nanotechnology for Advanced Wound Dressings

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1310

Editor

Dr. Javad Esmaeili

E-Mail Website
Guest Editor
Department of Applied Science, University of Quebec at Chicoutimi, Chicoutimi, QC G7H 2B1, Canada
Interests: wound dressing; biomaterial; hydrogels; drug delivery systems; nanotechnology

Special Issue Information

Dear Colleagues,

Wound healing is a complex and dynamic biological process, and when it fails to progress correctly, it can lead to chronic, non-healing wounds that represent a significant global healthcare burden. The challenge of chronic wounds, exacerbated by an aging population and rising rates of conditions like diabetes, underscores the urgent need for innovative therapeutic strategies.

This Special Issue, "Biomaterials and Nanotechnology for Advanced Wound Dressings", aims to gather cutting-edge research at the intersection of materials, nanotechnology, and regenerative medicine. We will explore how novel biomaterials and nanotechnology-based systems are revolutionizing wound care by developing multifunctional wound dressings and also providing active and smart support for the healing cascade. We invite original research articles and reviews that cover a wide range of topics, including but not limited to the following:

  • The design and synthesis of next-generation wound dressings, such as hydrogels, electrospun nanofibers, and foams.
  • The application of nanoparticles and nanocomposites for targeted delivery of therapeutic agents in wound dressings (e.g., antimicrobials, growth factors, antioxidants).
  • The use of responsive or "smart" biomaterials that sense the wound environment (e.g., pH, temperature) and release drugs on demand.
  • Strategies for tissue engineering, including the use of scaffolds for skin regeneration and scarless healing.
  • The development of diagnostic and prognostic nanodevices for real-time wound monitoring.
  • Preclinical and clinical studies evaluating the efficacy and biocompatibility of these advanced therapeutic systems.

By showcasing the latest advancements in biomaterials and nanotherapeutics, this Special Issue will provide a comprehensive overview of a rapidly evolving field. We look forward to receiving your contributions and collectively advancing the science of wound healing.

Dr. Javad Esmaeili
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound dressings
  • wound healing
  • biomaterials and nanotechnology
  • regenerative medicine
  • targeted delivery

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Published Papers (2 papers)

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Research

17 pages, 6379 KB  
Article
A Hydrogel Delivery System Based on Selenium Nanoparticles and bFGF for Promoting the Repair of Skin Wounds
by Yue Wang, Ruoyang Chen, Chaoqun Wang, Pei Zheng, Min Chen and Huihui Lu
Biomedicines 2026, 14(6), 1401; https://doi.org/10.3390/biomedicines14061401 (registering DOI) - 22 Jun 2026
Viewed by 147
Abstract
Objectives: Skin wound repair has long remained a crucial clinical challenge, in response to which, in this study, we propose a novel injectable hydrogel delivery system. In particular, we focus on the efficient delivery of bioactive factors and modulation of the local wound [...] Read more.
Objectives: Skin wound repair has long remained a crucial clinical challenge, in response to which, in this study, we propose a novel injectable hydrogel delivery system. In particular, we focus on the efficient delivery of bioactive factors and modulation of the local wound microenvironment. Methods: The hydrogel integrates selenium nanoparticles (SeNPs) and basic fibroblast growth factor (bFGF), which serve as key therapeutic components in the proposed system, and are additionally co-integrated with oxidized hyaluronic acid (OHA) and heparin-grafted carboxymethyl chitosan (CMCS-g-Hep) to construct a multifunctional SeNPs/bFGF-loaded CMCS-g-Hep/OHA hydrogel network. Accordingly, this proposed hydrogel was systematically evaluated using chemical synthesis, physicochemical characterization, in vitro cellular assays, and C57BL6J mice studies, which we used to jointly assess the biocompatibility and wound-healing efficacy of the proposed system. Results: The results demonstrated that the hydrogel enabled sustained bFGF release and was capable of significantly enhancing fibroblast proliferation, migration, and collagen deposition. In a mouse skin defect model, treatment with the loaded hydrogel markedly accelerated wound closure. Additionally, we conducted mechanistic investigations to further illustrate that the hydrogel can modulate the wound microenvironment by regulating inflammatory and chemotactic signaling pathways. Conclusions: These findings suggest a promising therapeutic pathway for chronic wound repair. Full article
(This article belongs to the Special Issue Biomaterials and Nanotechnology for Advanced Wound Dressings)
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13 pages, 1896 KB  
Article
An In Vitro Study on the Efficacy of Green Synthesized Silver Nanoparticles on Surgical Site Infections and Healings
by Gürkan Güneri and Merve Keskin
Biomedicines 2026, 14(3), 634; https://doi.org/10.3390/biomedicines14030634 - 12 Mar 2026
Viewed by 737
Abstract
Background/Objectives: The healing rate of wounds resulting from postoperative abdominal surgery interventions increases as the inflammation and infections in the wound are reduced. However, antibiotic resistance among microorganisms increases the incidence of surgical site infections (SSIs). Therefore, the need for new products [...] Read more.
Background/Objectives: The healing rate of wounds resulting from postoperative abdominal surgery interventions increases as the inflammation and infections in the wound are reduced. However, antibiotic resistance among microorganisms increases the incidence of surgical site infections (SSIs). Therefore, the need for new products that exhibit antimicrobial and anti-inflammatory activities, in addition to antibiotics, is increasing. Methods: Silver nanoparticles (CO-AgNPs) were obtained using the green synthesis technique with Cydonia oblonga L. leaves, which constitute a significant amount of waste, and the effects of the obtained nanoparticles on in vitro wound healing were determined. Results: It was observed that CO-AgNPs inhibited myeloperoxidase and collagenase, enzymes that negatively affect wound healing. Furthermore, they exhibited good antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus, which are common hospital pathogens. The CO-AgNPs could exhibit enhanced wound-healing properties by inhibiting microorganisms. Conclusions: It was clear that the development of new, environmentally friendly, and biocompatible products containing CO-AgNPs could be feasible, particularly for wound healing following infected abdominal surgery. Full article
(This article belongs to the Special Issue Biomaterials and Nanotechnology for Advanced Wound Dressings)
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