Decoding Glioblastoma: Molecular Pathology and Innovative Therapeutic Approaches

A Special Issue of Biomedicines (ISSN 2227-9059) belonging to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 121

Editor


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Guest Editor
1. State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Neurosurgery, Peking University Third Hospital, Beijing, China
2. Center for Precision Neurosurgery and Oncology, Peking University Health Science Center, Peking University, Beijing, China
3.Center for Oculocranial Pressure Instability Disorders (COPID), Henan Academy of Innovations in Medical Science (AIMS), Zhengzhou, China
Interests: glioblastoma; molecular pathology; tumor heterogeneity; targeted therapy; immunotherapy

Special Issue Information

Dear Colleagues,

Glioblastoma remains the most aggressive and lethal primary brain tumor in adults, associated with profound molecular heterogeneity, therapy resistance, and extremely poor clinical outcomes. Despite standard treatments including surgery, radiotherapy, and chemotherapy, long-term survival remains dismal, underscoring the critical need to advance our understanding of its molecular pathology and develop innovative therapeutic strategies. This urgent clinical demand highlights the significance of translating cutting-edge basic research into effective clinical applications. We are pleased to invite you to contribute high-quality original research and review articles to this Special Issue.

This Special Issue aims to integrate recent advances in molecular pathology and emerging therapies for glioblastoma, providing a comprehensive overview of state-of-the-art research and promoting interdisciplinary communication. The topic aligns well with the scope of Biomedicines, which focuses on translational biomedical research, molecular mechanisms, drug development, and clinical innovation. By gathering high-impact studies, this Special Issue intends to form a cohesive collection of at least 10 articles, with the potential for publication in book format to maximize academic influence.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Molecular pathology and genetic/epigenetic alterations in glioblastoma
  2. Tumor heterogeneity, microenvironment, and mechanisms of therapy resistance
  3. Novel biomarkers for diagnosis, prognosis, and therapeutic monitoring
  4. Targeted therapy, immunotherapy, and combination strategies
  5. Innovative drug delivery systems and nanotherapeutic approaches
  6. Translational research and clinical trial advances

We look forward to receiving your contributions.

Dr. Chenlong Yang
Guest Editor

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Keywords

  • glioblastoma
  • molecular pathology
  • tumor heterogeneity
  • targeted therapy
  • immunotherapy
  • drug resistance
  • biomarkers
  • translational medicine
  • drug delivery system

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