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Biomedicines
Special Issues
Gut Microbiota and Regulation of Metabolism
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Gut Microbiota and Regulation of Metabolism

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 813

Special Issue Editors

Dr. Xiaoyue Wu

E-Mail Website
Guest Editor
Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Interests: NAFLD; inflammatory bowel disease; gut-liver cross talk; nutrition; diets; dietary supplements; fasting; metabolic regulations
Dr. Zhan Zhang

E-Mail Website
Guest Editor
Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, China
Interests: gut microbiota; inflammatory bowel disease; colon cancer; non-alcoholic fatty liver disease

Special Issue Information

Dear Colleagues,

The Special Issue aims to explore the intricate relationship between the gut microbiota and metabolic processes, shedding light on the profound implications for human health and disease. Recent research has unveiled the pivotal role played by the gut microbiome in modulating host metabolism, influencing nutrient absorption, energy homeostasis, immune response and even contributing to the development of metabolic disorders.

This Special Issue invites authors to contribute original research articles and reviews that delve into the molecular mechanisms underpinning the crosstalk between gut microbes and host metabolism. Topics of interest include microbial metabolites, host–microbiota interactions and the impact on diseases such as inflammatory bowel disease, colon cancer, and non-alcoholic fatty liver disease. Additionally, we encourage submissions that explore therapeutic interventions targeting the gut microbiota to regulate metabolism.

By fostering a comprehensive understanding of these complex interactions, this Special Issue seeks to advance the field and provide valuable insights for researchers, clinicians and policymakers. Authors are encouraged to contribute cutting-edge research that elucidates the role of the gut microbiota in metabolic regulation and opens new avenues for personalized approaches to enhance human health.

Dr. Xiaoyue Wu
Dr. Zhan Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • non-alcoholic fatty liver disease
  • inflammatory bowel disease
  • colon cancer
  • gut–liver cross talk
  • dietary supplements
  • metabolic regulations

Published Papers (1 paper)

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Review

12 pages, 660 KiB  
Review
Improved Gut Health May Be a Potential Therapeutic Approach for Managing Prediabetes: A Literature Review
by Nosipho Rosebud Dimba, Nhlakanipho Mzimela and Andile Khathi
Biomedicines 2024, 12(6), 1275; https://doi.org/10.3390/biomedicines12061275 - 8 Jun 2024
Viewed by 408
Abstract
Given the growing global threat and rising prevalence of type 2 diabetes mellitus (T2DM), addressing this metabolic disease is imperative. T2DM is preceded by prediabetes (PD), an intermediate hyperglycaemia that goes unnoticed for years in patients. Several studies have shown that gut microbial [...] Read more.
Given the growing global threat and rising prevalence of type 2 diabetes mellitus (T2DM), addressing this metabolic disease is imperative. T2DM is preceded by prediabetes (PD), an intermediate hyperglycaemia that goes unnoticed for years in patients. Several studies have shown that gut microbial diversity and glucose homeostasis in PD or T2DM patients are affected. Therefore, this review aims to synthesize the existing literature to elucidate the association between high-calorie diets, intestinal permeability and their correlation with PD or T2DM. Moreover, it discusses the beneficial effects of different dietary interventions on improving gut health and glucose metabolism. The primary factor contributing to complications seen in PD or T2DM patients is the chronic consumption of high-calorie diets, which alters the gut microbial composition and increases the translocation of toxic substances from the intestinal lumen into the bloodstream. This causes an increase in inflammatory response that further impairs glucose regulation. Several dietary approaches or interventions have been implemented. However, only a few are currently in use and have shown promising results in improving beneficial microbiomes and glucose metabolism. Therefore, additional well-designed studies are still necessary to thoroughly investigate whether improving gut health using other types of dietary interventions can potentially manage or reverse PD, thereby preventing the onset of T2DM. Full article
(This article belongs to the Special Issue Gut Microbiota and Regulation of Metabolism)
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