The Human Proteinomics in Disease, Diagnostics and Translation into Precision Medicine: Current Status and Future Prospects—2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 886
Special Issue Editor
2. Consulting Services Department, 21 HealthStreet Ltd., London SW16 3JY, UK
Interests: precision medicine; drug discovery; biotechnology; functional genomics; proteomics; biomarkers; companion diagnostics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It gives us great pleasure to invite researchers and scientists to contribute to this MDPI Special Issue by Biomedicines, which focuses on the human proteome in health, disease and therapy. Proteins are the primary functional effectors in human biology and are involved in health and diseases. The human proteoforms are rich in diversity, and deciphering their structure and function is critical to both basic and translational research. The launch of this Special Issue is particularly timely, as we celebrate more than 20 years of human proteome accomplishments and look forward to the next generation of proteomics advancements.
Since the inception of the Human Proteome Organization (HUPO) and its first World Congress in November 2002, its visionary goal has been the translation of the code of life. The HUPO international, collaborative initiative “The Human Proteome Project (HPP)” (a Grand Challenge Project, “A Function for Each Protein”) aims to transform our knowledge of the human proteome and map it in its entirety, systematically utilizing state-of-the-art proteomics methods and software, available platform technologies and emerging techniques. Undoubtedly, this will not only enhance our holistic understanding of human biology at both the cellular and molecular levels but will also establish a foundation for the development of diagnostic, prognostic, therapeutic and preventive medical applications.
The HPP effort today is better coordinated and more focused. Nowadays, the HPP comprises two strategic initiatives: chromosome-centric (C-HPP) and biology/disease-centric (B/D-HPP). To date, protein expression has been credibly detected for 93.2% of the predicted proteins encoded in the human genome. Conversely, the number of proteins in existence (missing proteins) has been reduced.
To mark the continued achievements in human proteomics, this second edition Special Issue of Biomedicines aims to expand and contribute to the knowledge of the human proteome and will describe the following:
- Application of proteomics in a variety of biological and clinical studies;
- Cutting-edge technologies, techniques and analytical tools in proteomics;
- Integration with other “omics” platforms;
- Recent progress in biology and disease-driven proteome knowledge;
- Emergence of translational activities from protein profiling;
- Discerning protein structure/function and molecular processes;
- Protein expression including sequence variants and splice variants, post-translational modification, sub-cellular localization, physiology and pathologies;
- Protein–protein interactions, molecular pathways and networks (interactomics);
- Protein therapeutic target discovery, validation, drug discovery, biomarkers and companion diagnostics;
- Current trends in computational biology, bioinformatics and databases associated with the human proteome;
- Precision and translational medicine of human proteome;
- Human proteome and proteomics translational research.
Dr. M. Walid Qoronfleh
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- proteomics
- human proteome
- systems biology
- precision medicine
- biomarker(s)
- disease pathogenesis
- diagnostics
- mass spectrometry
- tandem mass spectrometry
- LC-MS/MS
- peptides and proteins
- multiplex protein analysis
- protein network
- protein–protein interaction
- splice variants
- post-translational modifications
- omics analysis
- data integration
- bioinformatics
- artificial intelligence
- deep learning
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